Senior Director, Commercial Operations

Senior Director, Commercial Operations at INOVIO Pharmaceuticals, Inc.

INOVIO is a biotechnology company focused on developing and commercializing DNA medicines to help treat and protect people from HPV-related diseases, cancer, and infectious diseases. INOVIO’s technology optimizes the design and delivery of innovative DNA medicines that teach the body to manufacture its own disease‑fighting tools. For more information, visit

The Senior Director, Commercial Operations will serve as a key commercial architect supporting the successful launch and commercial execution of INO‑3107, Inovio’s lead product for Recurrent Respiratory Papillomatosis. This leader will design, stand up, and scale the commercial infrastructure—spanning KPI creation and monitoring, forecasting, analytics, CRM systems, field operations, and commercial process optimization—to ensure a seamless transition from clinical readiness to commercial excellence.

The role is based in our Plymouth Meeting, PA office, with a hybrid schedule.

As a strategic member of the commercial team, this role partners closely with Sales, Marketing, Market Access, Finance, Supply Chain, and IT to develop the systems, processes, and insights that equip Inovio’s first launch brand for success in the rare disease marketplace.

• Partner with the CCO and leadership team to operationalize commercial strategy aligned with INO‑3107 launch milestones and revenue goals.
• Develop a scalable infrastructure that supports Inovio’s entry into the commercial market, including field deployment planning, incentive design, and governance frameworks.
• Lead launch and annual planning cycles, translating organizational priorities into forecasting models, frameworks, and KPI dashboards.

• Support revenue forecasting, demand modeling, and patient‑flow analytics in collaboration with Finance and Market Access.
• Develop integrated dashboards to monitor performance across field, brand, patient services, and specialty distribution partners.
• Drive data‑driven insights on market uptake, payer dynamics, and HCP engagement patterns to guide strategic adjustments.

• In partnership with the Contract Sales Organization (CSO) support field operations infrastructure—including CRM (Salesforce), call planning, territory optimization, and incentive compensation.
• Partner with Sales Leadership to define sales governance, quota methodology, and data‑driven targeting aligned with the limited RRP prescriber base.
• In partnership with the Contract Sales Organization (CSO), ensure effective onboarding, training, and field readiness through performance insights, learning tools, and execution dashboards.

• Own commercial technology, including CRM, BI platforms, and data integration across finance, distribution, and patient services.
• Develop and enforce commercial data governance and validation standards.
• Lead vendor relationships across CRM, analytics, and data aggregation partners to ensure seamless flow of patient‑ and prescriber‑level data.

• As INOVIO grows, build and lead a high‑performing commercial operations team capable of scaling with Inovio’s commercial evolution.
• Foster collaboration across Commercial, IT, Finance, and Clinical teams to ensure smooth integration of data and processes.
• Serve as a commercial operations thought leader—bringing best practices from biotech launches and rare disease environments.

• Strategic and operational balance—equally capable of designing frameworks and executing details.
• Strong analytical acumen and commercial intuition specific to rare disease and buy‑and‑bill models.
• Effective cross‑functional communicator and facilitator of collaboration between science‑driven and commercial teams.
• Hands‑on builder who thrives in a launch environment without legacy infrastructure.
• Bachelor's degree in business, Finance, Life Sciences, or Analytics; advanced degree (MBA, MS, MPH, Pharm
  
  D) preferred.
• Minimum 10–15 years of progressive experience in commercial operations, analytics, or…