Senior Director, Participant Recruitment and Retention

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Senior Director, Participant Recruitment and Retention provides strategic leadership for the development and execution of global participant recruitment, engagement, diversity, and retention strategies across Madrigal Pharmaceuticals' clinical development portfolio. This leader will establish innovative, patient-centered approaches that accelerate enrollment, improve participant retention, and enhance the overall clinical trial experience while supporting the company's mission to deliver transformative therapies to patients with metabolic and liver diseases.

Working collaboratively with Clinical Operations, Medical Affairs, Regulatory Affairs, Biostatistics, Data Management, Clinical Supply, Patient Advocacy, Legal, and external partners, the Senior Director will develop enterprise-wide recruitment capabilities that improve study performance and support successful clinical trial execution.

This position requires a strategic, data-driven leader with deep expertise in clinical trial recruitment, decentralized clinical trial methodologies, patient engagement, digital recruitment technologies, health equity, and vendor management.

• Develop and execute Madrigal's enterprise participant recruitment and retention strategy across all clinical development programs.
• Establish long-term strategic initiatives that improve enrollment timelines, participant diversity, retention, and overall study performance.
• Build scalable recruitment capabilities, processes, standards, and governance across the organization.
• Serve as the organizational subject matter expert on participant recruitment, engagement, retention, and patient-centric clinical trial design.
• Provide executive leadership with enrollment forecasts, strategic recommendations, risk assessments, and mitigation plans.

• Lead development of protocol-specific recruitment and retention strategies for Phase I-IV clinical studies.
• Collaborate with study teams during protocol development to optimize study feasibility, participant burden, and recruitment success.
• Evaluate recruitment challenges and proactively implement innovative solutions to accelerate enrollment.
• Develop country, regional, and site-specific recruitment strategies based on epidemiology, competitive landscape, and operational feasibility.
• Integrate digital technologies, social media, community outreach, and patient engagement initiatives into recruitment plans.

• Design participant-centric initiatives that improve study awareness, enrollment, engagement, and long-term retention.
• Develop participant communication strategies throughout the clinical trial lifecycle.
• Partner with patient advocacy organizations and community leaders to improve trial accessibility and awareness.
• Champion health equity initiatives that increase participation among historically underrepresented populations.
• Ensure participant feedback is incorporated into continuous improvement efforts.

• Partner closely with Clinical Operations to ensure recruitment strategies align with study execution plans.
• Collaborate with cross-functional teams to ensure recruitment materials comply with applicable regulations and ethical standards.
• Work with Clinical Supply, Data Management, and Biostatistics to anticipate operational impacts related to enrollment.
• Support Business…