VP, Scientific IT Business Partner

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH.

Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.

To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Vice President, Scientific IT Business Partner will lead Madrigal’s Scientific IT Business Partnership, supporting the company’s Research & Development and Technical Operations organizations. This role will serve as the senior IT partner to the R&D and Tech Ops executive leadership teams, translating functional strategy into technology roadmaps, portfolio priorities, operating capabilities, and delivery outcomes.
As Madrigal continues to grow, the technology needs across R&D and Tech Ops are becoming more complex, interconnected, and critical to the company’s ability to execute. This leader will help mature how IT supports the scientific value chain, bringing both domains together with a breadth to lead across an interconnected landscape, ensuring the right systems, data, integrations, processes, partners, and internal capabilities are in place to support clinical development, regulatory progression, quality, manufacturing, supply, and continued operational scale.  

This is a senior IT leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution. The VP will own the Scientific IT portfolio, budget, roadmap, and business partnership model, while working closely with Data, AI, Cybersecurity, Enterprise Architecture, Infrastructure, PMO, and IT Compliance to ensure solutions are scalable, compliant, secure, and aligned to enterprise standards.  

A key part of this IT leadership role will be supporting R&D and Tech Ops as those functions build more internal business capability and reduce reliance on external partners. As functional ownership moves further in-house, this leader will ensure the technology roadmap, systems, data, integrations, governance, and support model evolve alongside the business. The VP will partner with R&D and Tech Ops leaders to anticipate how those shifts affect process ownership, compliance needs, decision-making, and operating rhythms, and translate those needs into practical technology plans.

** Key Responsibilities
**** Scientific IT Strategy & Executive Partnership
*** Serve as the senior IT business partner for Madrigal’s R&D and Tech Ops organizations, building trusted relationships with the respective ELT members and their leadership teams.
* Translate R&D and Tech Ops business strategies into multi-year technology roadmaps, investment priorities, and portfolio plans.
* Develop sufficient digital breadth across the scientific value chain to anticipate cross functional implications and ensure technology decisions made within one domain support the broader R&D…