PhD Student in time-resolved serial crystallography of enzymatic reactions

The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science and economy. PSI is committed to the training of future generations.

Therefore, about one quarter of our staff are post-docs, post-graduates or apprentices. Altogether, PSI employs 2300 people.
For the Time-Resolved Crystallography Group in the PSI Center for Life Sciences we are looking for a

• Conduct a PhD project on enzyme reaction mechanisms using time-resolved serial crystallography at synchrotron and XFEL facilities
• Prepare and run temperature-controlled experiments (e.g., T-jump) to probe transient intermediate states
• Analyze and interpret high-resolution crystallographic datasets to extract mechanistic insight into enzymatic processes
• Apply - and where needed, help advance - biophysical methods supporting protein structure/function analysis
• Optimize experimental sample preparation, including protein expression and purification

• Master’s degree or equivalent in Chemistry, Biochemistry, Molecular Biophysics, or a related field
• Hands-on experience with biophysical techniques (e.g., CD, fluorescence spectroscopy, ITC) and protein purification (e.g., FPLC)
• Strong analytical skills, initiative, and the ability to thrive in a multidisciplinary team
• Prior experience in crystallography (macromolecular crystallography, serial crystallography, crystallographic data processing/refinement) is highly valued

Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.

For further information, please contact Dr Tobias Weinert, phone .

Please submit your application online by 31 January 2026 (including addresses of referees) for the position as a PhD Student (Index-. ).