Senior Scientist, Translational Medicines & Biomarkers

Chesterbrook, PA

At Avalo (ahh-vah'-low), we are 100% focused on developing treatments for immune-mediated inflammatory diseases with large unmet needs that affect millions worldwide. Our strategy is to develop medicines that target the IL-1β pathway, which is a central driver of the inflammatory process.

We share a commitment to teamwork, passion for science, and dedication to patients suffering from acute and chronic inflammatory disorders. Our collective expertise in discovery, development, and regulatory approvals is evidenced in our strong individual track records of advancing multiple therapeutic programs to successful commercialization.

The Senior Scientist ,Translational Medicines & Biomarkers will provide scientific leadership and support across clinical and preclinical development programs.

The successful candidate will be responsible for developing and executing translational and biomarker strategies, interpreting biomarkers data integration with PK, PD, ADA, NAb, efficacy, and safety data, and supporting the advancement of clinical-stage and early pipeline programs.

This role requires a scientist who can independently analyze complex datasets, develop scientifically rigorous conclusions, and communicate actionable recommendations to multidisciplinary teams and senior leadership.

• Develop and implement biomarker and translational strategies for clinical-development programs
• Identify pharmacodynamic and potentially predictive, prognostic, and patient-stratification biomarkers
• Provide immunoassays (including PK and PD) input into clinical protocols and sampling schedules.
• Ensure that biomarker plans address the key clinical-development questions for each program
• Evaluate assay readiness, feasibility, validation requirements, and sample-handling considerations

• Lead or support analysis of clinical biomarker datasets
• Integrate biomarker results with efficacy, safety, PK, ADA, NAb, and patient-characteristic data to generate a clear PD picture
• Evaluate response-associated biomarkers, disease subgroups, and potential confounding factors
• Distinguish exploratory signals from robust and biologically meaningful findings
• Develop clear scientific conclusions and recommendations
• Identify additional analyses required to address emerging questions

• Evaluate target biology, mechanisms of action, and disease rationale
• Develop translational plans for early development programs
• Design or recommend experiments to test key mechanistic hypotheses
• Lead CRO oversights, including assay designs, assays executions and raw data analysis.
• Support candidate-selection and indication-selection decisions

• Work closely with all stakeholders to ensure program success
• Collaborate with CROs, bioanalytical laboratories, consultants, and academic experts
• Represent Translational Medicine and Biomarkers in program team meetings
• Communicate complex scientific findings clearly to scientific stakeholders

• Prepare internal data-review presentations and program recommendations
• Conduct literature reviews and competitive landscape assessments

• PhD or advanced equivalent degree in immunology, molecular biology, biomedical engineering or a related discipline
• 5-8 years of experience in pharmaceutical development, or translational clinical research, specifically in the I&I space
• Experience in hands-on programming for single cell RNA-seq and protein biomarkers analysis including statistics and machine learning knowledge-significant advantage.
• Strong understanding in in-vitro cell-based assays, and in-vivo…