Co-op​/DMPK NCE Bioanalytical

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines.

We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included.

Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

The GSK Drug Metabolism and Pharmacokinetics (DMPK) organization is responsible for the delivery of key DMPK support (in vitro, pharmacokinetic, and bioanalytical) that helps drive early drug discovery programs. Within that structure, the Bioanalytical team is responsible for the quantitation of drug and drug related molecules in samples generated both in vitro and in vivo.

Additionally, a key remit of the U.S. DMPK organization is the modernization and optimization of processes to allow for increased throughput and efficiency. A pivotal aspect of that remit is the expansion of DMPK assays by implementing new bioanalytical approaches. The support of these assays presents an opportunity for a student to learn and contribute via sample preparation, LC-MS/MS and SPE-MS/MS analysis, and data interpretation and tracking.

The GSK Drug Metabolism and Pharmacokinetics group is seeking a highly motivated individual to join our Bioanalytical team for a 6 to 12-month internship. The successful candidate’s primary responsibility will be assisting in the analysis of DMPK screening assays using both LC-MS/MS and high throughput SPE-MS/MS platforms. Through working closely with Bioanalytical team members the candidate will learn key concepts of mass spectrometry analyses, including sample preparation, instrument/data analysis software, and data interpretation.

Additionally, a high achieving candidate will have opportunities to evaluate related analytical methodologies in an effort to optimize workflows. The ability to work both independently and within a team environment is expected.

Responsibilities include but are not limited to:

• Learn the basic principles of qualitative LC-MS/MS and SPE-MS/MS through the analysis of in vitro DMPK assay samples.
• Analyze, interpret, and present data to DMPK staff.
• Help with the implementation and assessment of new methodologies for sample analysis.
• Assist in troubleshooting and optimizing workflows based on experiences during instrument use and data analysis.

• Pursuing a BS, MS or PhD degree in Chemistry, Biology or similar discipline.
• Experience in Chemistry or Biology laboratory.
• Must be able to work full-time (35 hours/week) throughout the duration of the 6-month co-op (March ~ September 2027).
• Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible.

• Organic and/or analytical chemistry.
• Liquid chromatography.
• Mass…