Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

2 days ago Be among the first 25 applicants

Bio Marin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.

From research and discovery to post‑market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first‑in‑class and best‑in‑class therapeutics that provide meaningful advances to patients who live with genetic diseases.

We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team.

They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders.

• Conduct research on genetic metabolic diseases
• Contribute to novel therapeutic programs based on innovative, ground‑breaking discoveries that could lead to new, high‑impact opportunities for patients
• Perform research and publish findings in high‑impact journals and present research at major conferences
• Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan
• Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums
• Write, review and contribute to study synopses, protocols, study reports and regulatory documents
• Collaborate with various Bio Marin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
• Participate in multi‑disciplinary drug development teams and may lead sub‑teams
• Excellent written and verbal communication
• Build and foster productive cross‑functional collaborations both within and external to Bio Marin
• Execute hands‑on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail‑vein), in‑life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. Provide daily care and monitoring of mice or rats, including health checks and documentation.
• Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation.
• Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies.
• Work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines.
• Share knowledge and understanding with other team members
• Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs.
• Willingness to work on site full time including off hours and weekends based on study needs

• Demonstrated experience in metabolic biology/disease research…