Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

We are looking for a Scientist II in Bio Marin's In Vivo, Enzymatic & Metabolic Therapeutic Area to design and execute key in vivo studies for therapeutic development. This is a full‑time on‑site role based in Petaluma, CA.

Bio Marin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Our worldwide R&D engine covers basic research to post‑market clinical development, focusing on first‑in‑class therapeutics for genetic diseases.

• Conduct research on genetic metabolic diseases
• Contribute to novel therapeutic programs based on innovative, ground‑breaking discoveries that could lead to new, high‑impact opportunities for patients
• Perform research and publish findings in high‑impact journals and present research at major conferences
• Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan
• Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums
• Write, review and contribute to study synopses, protocols, study reports and regulatory documents
• Collaborate with various Bio Marin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
• Participate in multi‑disciplinary drug development teams and may lead sub‑teams
• Excellent written and verbal communication
• Ability to build/foster productive cross‑functional collaborations both within and external to Bio Marin
• Execute hands‑on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail‑vein), in‑life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required.
• Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation.
• Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies.>
• Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines.
• Share your knowledge and understanding with other team members
• Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs.
• Other duties as assigned
• Willingness to work on site full time including off hours and weekends based on study needs.

• Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record
• Strong analytical, problem‑solving, and decision‑making skills
• Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities
• Excellent oral and written communication skills
• Passion for contributing your scientific skills to develop therapies for patients in need
• Must be able to utilize computer databases for analysis, data entry, and point of care observations
• Must be able to work under time constraints with minimal direction of day‑to‑day responsibilities, including collaboratively working with multidisciplinary teams
• Must be able to work with external regulatory agencies and accreditation groups
• Some "off-core business hours" work required
• Complete all company training requirement
• Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks
• This position is an on‑site critical required position

• PhD in a related subject area with demonstrated in vivo research experience in metabolic disease
• Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases
• Extensive hands‑on experience with rodent in vivo work in the metabolic field

Location:

Petaluma, CA. Full‑time on‑site based in Petaluma, CA with occasional work on site in San Rafael, CA.

Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.