Associate Scientist, Computational Biology

Philadelphia, PA Category:
Computational Bio and Research Type:
Full-time

Min.

Experience:

Some Experience

Position Title:

Associate Scientist, Computational Biology

Location:

Hybrid/Philadelphia, PA  (
*** 3 Days on-site in Philadelphia, PA)

Reports to:

Scientist, Computational Biology Department:
Research – Computational Biology Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases.

The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio’s headquarters and labs are located in Philadelphia, PA. For more information, please visit and connect with us on Linked In.Uniquely

Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients’ own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team.

In this way, we are not only working to improve the lives of patients, but of everyone involved. #Cabaletta Crew. We’re proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work About the Position:
The Associate Scientist, Computational Biology will build and maintain programmatic and agentic workflows that clean, transform, and merge large, feature-rich datasets — primarily flow cytometry, MSD, and dPCR data — into analysis-ready information. Working under the guidance of senior computational biology staff, they will collaborate with Research, Translational, Manufacturing, and Clinical teams to visualize and correlate data across the organization, surface key scientific questions, and communicate clear summaries of their analyses to stakeholders.

Responsibilities:
Design, build, and maintain programmatic and agentic workflows to support recurring computational biology tasks, including cleaning, transforming, and merging large-scale biological datasets with many features.

Mine public and internal databases for relevant biological and disease-related information.

Develop and automate interactive data visualizations and dashboards.

Perform correlative analyses and produce clear, intuitive summary reports of data exploration and analyses for scientific and non-scientific audiences.

Communicate results and recommendations to stakeholders, including scientific colleagues and collaborators.

Maintain thorough documentation of workflows and analytical methods in accordance with SOPs.

Required Qualifications:

MS in computational biology, bioinformatics, computer science, or a related field plus 1–2 years of relevant experience; or a BS with additional demonstrated experience in computational and programmatic analysis of biological data.

Strong foundation in computer science, statistics, mathematics, and biology.

Proficient in Python,…