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Histotechnologist II

Job in Phoenix, Maricopa County, Arizona, 85001, USA
Listing for: Exact Sciences
Full Time position
Listed on 2026-01-15
Job specializations:
  • Healthcare
    Medical Technologist & Lab Technician, Clinical Research, Medical Science
Job Description & How to Apply Below

Help us change lives

At Exact Sciences, we’re helping change how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you’re working to help others.

Position Overview

The Histotechnologist II will perform a variety of histology laboratory procedures used to produce tissue slides and support the general laboratory duties expected to be performed in a CLIA/CAP-certified histopathology laboratory. The Histotechnologist II shall adhere to all safety, quality controls, and procedures, and learn and perform all functions of histology, pathology, and molecular aspects needed in the laboratory.

Essential Duties

Include, but are not limited to, the following:

  • Label documentation of formalin-fixed paraffin-embedded (FFPE) blocks, slides, and microcentrifuge tubes by following standard operating procedures (SOPs).
  • Routine sectioning, fixation, and processing procedures related to hematoxylin and eosin (H&E) staining/slide production for fresh frozen (FF) and FFPE samples according to SOPs.
  • Prepare and perform processing procedures for DNA and RNA analyze extraction according to SOPs.
  • Label accessioned samples/sample containers and test requisition form using the laboratory labeling system with assigned number specific to the patient case from laboratory information system (LIS) accessioning.
  • Prepare and perform all aspects related to the routine processing of FF tissue samples, to include preparation for tumor estimate procedure, according to SOPs.
  • Accession and enter data of received patient samples and specific test request into LIS according to SOPs.
  • File and store all slides and FFPE tissue blocks.
  • Assist with the initial quality review of incoming specimens.
  • Maintain all histology equipment and corresponding documentation; including, but not limited to, quality control worksheets, preventive maintenance records, and day-to-day maintenance.
  • Enter data into the histology portion of the information management system (IMS).
  • Perform routine and/or non-routine histology procedures, and regularly review work to ensure work is carried out in accordance with established policies and procedures.
  • Perform microdissection of unstained slides in accordance with markings of stained slides provided.
  • Prepare reagents, solutions, and controls.
  • Perform and document equipment maintenance and calibration.
  • Assist in sample returns, as needed.
  • Interact with pathologists and laboratory staff, in accordance with SOPs, to ensure specimens are processed in a timely manner with high quality.
  • Provide materials and reagent receipt and management in accordance with SOPs.
  • Provide technical assistance to other staff, as needed.
  • Assist in training team members, as needed.
  • Perform H&E staining.
  • Monitor and process the histology queue for various tasks that need to be performed and perform these tasks with minimal supervision.
  • Ability to prioritize and drive to results with a high emphasis on quality.
  • Ability to work independently as well as part of a team.
  • Ability to multi-task and rapidly switch directions to accommodate changes in study designs.
  • Display high attention to detail.
  • Strong interpersonal and written and verbal communication skills.
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
  • Support and comply with the company’s Quality Management System policies and procedures.
  • Maintain regular and reliable attendance.
  • Ability to act with an inclusion mindset and model these behaviors for the organization.
  • Ability to work designated schedule.
  • Ability to work nights and/or weekends, as needed.
  • Ability to work overtime, as needed.
  • Ability to use various types of laboratory equipment; including microscopes, microtomes, blades, strainers, and pipettes for extended periods of time.
  • May perform repetitious actions using lab tools.
  • Ability to use near vision to view samples at close range.
  • Ability to spend considerable periods of time concentrating, reading, or analyzing data, or applying…
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