Sr Mechanical Engineer

Position: Sr Staff Mechanical Engineer
Senior Staff Mechanical Engineer (Onsite in Wilsonville, OR)
Summary We are seeking a Senior Staff Mechanical Engineer to design, build, and test our next-generation automated wet-lab instruments. Based primarily on-site in Wilsonville, OR with partial remote flexibility, this role requires occasional travel to Twist in South San Francisco, CA and to vendor locations.

Responsibilities:

Use Solid Works to design multiple instruments that integrate liquid handling, consumable handling, imaging & robotics that meet or exceed System & Hardware requirements

Manage and use Solid Works AI Agents to create new hardware designs leveraging parts & assemblies already in Twist’s PDM environment

Specify all hardware (off-the-shelf and custom) for the instruments

Work with other team members to develop and refine requirements

Perform tolerance analysis as needed

Support contract manufacturers and vendors as the Mechanical Technical Lead for your designs

Work with other team members to execute and support Factory and Site Acceptance Testing Compile content and hold multiple design reviews as needed

Use Solid Works to design & build test fixtures as needed to de-risk concept features or test sub-systems

Support Process Systems Engineers as needed during Concept Development and all other project phases

Provide system fluidics and electrical design documentation

Build, debug, calibrate, and verify the instruments with help from technicians and Process System Engineers Create full models, part files, part drawings, assembly drawings & a BOM for the System Maintain full design control and release via 3D
- Experience (Dassault Systèmes)
Order & track parts for system builds

Provide updated designs for obsolete parts

Lead hardware design for next-generation custom instrumentation, from concept and feasibility through post-production support.

Provide concept architectures for Roadmap development

Required Skills:

12+ years of experience as a Senior Mechanical Engineer(or higher) and a 4-year degree in mechanical engineering, or 8 years of experience as a Senior Mechanical Engineer (or higher), with a graduate degree in mechanical engineering

Expert in Solid Works, with a proven record of delivering end-to-end design packages, complete engineering documentation, and fabrication-ready deliverables.

Lead Mechanical Engineer of at least 2 benchtop or larger instruments that went into Production Strong experience with robotics/mechatronics and specifying electronic devices

Extensive experience designing hardware for fluidics systems, including custom manifolds and integration of pumps, valves, sensors, regulators, etc.

Proven track record of collaborating with cross-functional teams—including engineers, scientists, and project managers—across the entire project lifecycle, from initial concept to post-release monitoring

Experience managing a CAD PDM system

Excellent communication and writing skills, and the ability to work in a fast-paced team environment

Very strong documentation skills

Comfortable working with evolving requirements and a dynamic work environment driving hardware designs for multiple projects

Proven ability to perform System Integration Proven ability to perform Systems Testing, including Factory/Site Acceptance Testing Additional Bonus

Skills:

Proficiency in 3DExperience

Experience with mechanical design for optical systems

In-depth knowledge and use of machine shop tools (band saws, Mill, drill press, sanders)
Experience performing electrical and electronics troubleshooting

Experience with Altium, Lucid, or other software tools that can be used to create wiring or plumbing diagrams

Experience in specifying device control

Experience compiling and releasing QA documentation

Experience as an Instrument Technical Lead or…