Vice President of Finance

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Giannakakos, Jay Edelberg, M.D. and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading Myo Kardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting‑edge discovery and translational research platform, a pipeline of late‑stage candidates, and an industry‑leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted.

With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Position Title: VP of Finance

Department: Finance

Reports To: Chief Financial Officer

Location: Princeton, New Jersey– On‑site 4 days per week (Mon to Thurs)

Kardigan is seeking a Vice President of Finance to lead the company’s finance function and serve as a senior strategic partner to R&D, clinical, and operational leadership. This role is designed for a highly analytical, business‑oriented finance leader with a trajectory toward broader enterprise leadership, including the potential to grow into a CFO role over time.

Reporting to the CFO, the VP of Finance will own financial planning and analysis, portfolio and capital analytics, and operational finance, while partnering closely with Accounting to ensure disciplined, scalable, and compliant financial operations. The successful candidate will bring deep biotech experience, strong quantitative rigor, and hands‑on experience supporting capital‑raising processes, with the ability to translate complex data into clear strategic insight in a fast‑growing, late‑stage biopharmaceutical company.

• Lead all FP&A activities, including annual budgeting, rolling forecasts, long‑range planning, and scenario modeling
• Develop sophisticated financial models to support program economics, clinical development planning, enrollment assumptions, and portfolio trade‑offs
• Establish a best‑in‑class, analytics‑driven finance function that informs prioritization, capital allocation, and strategic decision‑making
• Drive disciplined, data‑backed discussions around trade‑offs, risk, and return across programs and functions

• Design and own executive‑level reporting, dashboards, and performance metrics that enable faster, higher‑quality decisions
• Translate complex financial, clinical, and operational data into clear, actionable insights for executive leadership and program teams
• Track performance versus plan and proactively identify opportunities to improve efficiency, outcomes, and capital effectiveness
• Build and manage an integrated, portfolio‑level financial view across development programs, platforms, and initiatives
• Partner closely with R&D and program leadership to assess investment options, prioritization, and sequencing decisions
• Serve as a strategic finance partner on capital deployment decisions, ensuring alignment with company objectives and long‑term value creation
• Play a key role in capital‑raising efforts, including private…