Specialist GenAI Architect

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Let’s do this. Let’s change the world. In this vital role you will

have an opportunity to be a hands‑on architecture leader within the Applied AI – AI Productivity and Custom GPT Solutions Practice. The role defines and guides secure, scalable, reusable, and production‑ready GenAI solutions that enable Amgen organizations to adopt LLM‑powered assistants, agents, Custom GPTs, and AI‑enabled applications.

This role translates business needs into end‑to‑end technical designs, establishes reference architectures and guardrails, validates critical concepts through targeted prototypes, and guides engineering teams from solution discovery through production deployment and operational handover.

Responsibilities

GenAI Solution Architecture

• Lead end‑to‑end architecture for LLM‑powered assistants, agents, Custom GPTs, RAG solutions, and AI‑enabled applications across experience, model, retrieval, orchestration, integration, security, cloud, deployment, and observability layers.

• Translate functional and non‑functional use‑case requirements into architecture documents, diagrams, integration patterns, data flows, security models, deployment designs, and implementation guidance.

• Select appropriate patterns, including prompt engineering, RAG, agentic orchestration, workflow automation, traditional software logic, or model customization—based on quality, risk, scalability, latency, cost, and supportability.

• Architect solutions using ChatGPT Enterprise, MCP‑based apps, ChatGPT Skills, enterprise APIs, Databricks, vector search, governed data sources, and approved AI platforms.

• Design agentic and event‑driven solutions using OpenAI SDKs, Lang Chain/Lang Graph, n8n, APIs, webhooks, and human‑in‑the‑loop controls.

• Develop targeted proofs of concept and reference implementations to validate architecture decisions, reduce delivery risk, and accelerate engineering execution.

• Guide delivery teams through implementation and ensure delivered solutions remain aligned with approved architecture, security controls, engineering standards, and operational requirements.

Architecture Governance, Security, and Operations

• Conduct solution and architecture reviews; identify technical risks, platform constraints, security gaps, data‑governance concerns, and operational dependencies; and document decisions, assumptions, tradeoffs, and recommendations.

• Establish reusable reference architectures, solution patterns, technical standards, guardrails, and architecture decision records for enterprise GenAI adoption.

• Define non‑functional requirements covering privacy, security, responsible AI, performance, scalability, observability, auditability, maintainability, and total cost of ownership.

• Define safeguards for prompt injection, data leakage, unauthorized retrieval, insecure tool execution, excessive agency, secrets exposure, and inappropriate model outputs, including appropriate human oversight for high‑risk actions.

• Establish secure identity and access patterns using OAuth, service identities, delegated authorization, role‑based access control,…