Senior Principal Scientist, Upstream Process R&D

Senior Principal Scientist, Upstream Process R&D

Our Scientists are our Inventors. Through innovative thinking, state‑of‑the‑art facilities, cutting‑edge science, and technology, we collaborate to deliver the next medical breakthroughs. We are looking for a collaborative, self‑motivated scientific leader with expertise in downstream bioprocessing to join Biologics Process Research & Development (BPR&D) as a Senior Principal Scientist.

• Serve as a scientific leader to shape and drive innovation across the Biologics pipeline, strategy, and science.
• Anticipate and solve scientific and technical challenges across projects and functional teams, in a fast‑paced, multidisciplinary environment.
• Lead the development of robust and scalable upstream processes for biologics in various stages of clinical development, as well as process characterization and regulatory filings for successful commercialization.
• Improve upstream processes by increasing efficiency and cost‑effectiveness through research and innovation, while evaluating technologies and industry best practices.
• Collaborate with academia, industry, and vendors to facilitate the development and early adoption of novel process technologies.
• Contribute to strategic initiatives; work with senior leaders to establish overall project strategy and guide teams in its execution.
• Conceptualize, plan, and execute projects using effective organizational, prioritization, and problem‑solving skills.
• Stay updated on the scientific and regulatory landscape; contribute scientifically and build your reputation through conference participation.
• Represent BPR&D as a upstream bioprocess expert/co‑leader in internal and cross‑functional project teams.
• Supervise, coach, and develop talent within the functional area; guide career development; build strong, collaborative teams.
• Champion compliance and safety while promoting a culture of diversity, equity, and inclusion.

• Ph.D. with 10+ years, MS with 12+ years, or BS with 14+ years of industry experience in Chemical/Biochemical Engineering or a related field.

• Strong fundamental knowledge and subject matter expertise in cell‑culture process development for biologics, fed‑batch cell culture, bioreactor scale‑up and scale‑down, and recent advances.
• Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of cell‑culture process development.
• Track record of accomplishments in upstream bioprocessing with a history of peer‑reviewed publications and presentations. Strong understanding of cell metabolism and biochemical pathways relevant to bioprocessing.
• Knowledge of biologics CMC development.
• Ability to adapt to and prioritize complex objectives under tight timelines in a rapidly changing environment.
• Experience leading internal and external cross‑functional, matrixed teams.
• Demonstrated scientific leadership with significant, measurable project impacts across a diverse set of programs.
• Action‑oriented mindset with a capacity for creativity; ability to take initiative, innovate, iterate, and solve problems.
• Supervise, coach and mentor scientists to maximize talent development and utilization.
• Excellent interpersonal and communication skills.

• Leadership of CMC development teams.
• Experience with continuous biomanufacturing integrated with process‑analytical technologies.
• Intensified inoculum and perfusion process development.
• Expertise in media/solution development and chemistry.
• High‑throughput experimentation, automation, and process control.
• Knowledge of microbial fermentation.
• Cell culture predictive modeling (omics, metabolic flux analysis); statistics, data‑science, machine learning, artificial intelligence.

$ – $ (lowest‑to‑highest range). An employee’s position within the range will be based on several factors including education, qualifications, experience, skills, location, and business needs.

We offer a comprehensive package of benefits including medical, dental, vision, retirement benefits (401(k)), paid holidays, vacation, and sick days. More information…