Associate Principal Scientist, Continuous & Expression Technologies; Downstream - Onsite

Associate Principal Scientist, Continuous & Expression Technologies (Downstream) – Onsite

Merck – Rahway, NJ

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The Continuous & Expression Technologies (CET) Group within the Process Research & Development, Enabling Technologies department is seeking motivated and creative individuals. This is an opportunity to positively impact our company’s manufacturing platforms while actively supporting drug development in the biologics and vaccine arenas. CET is seeking an Associate Principal Scientist specializing in bioprocessing purification technologies for multiple therapeutic classes – at our site in Rahway, NJ.

• As an impactful contributor, shape and realize innovation across biologics’ pipeline, strategy, and science
• Advance best science incorporation into pipeline by collaborating with cross‑functional teams, from Research & Manufacturing, in a fast‑paced, multidisciplinary environment
• Lead development of robust and scalable technologies for downstream processes for biologics
• Identify areas for downstream process innovation/intensification and expand our technologies toolbox to address challenges at different stages of development (clinical, process characterization and commercialization)
• Contribute to strategic initiatives; partner with senior leaders to set overall project strategy, and guide teams towards its execution
• Conceptualize, plan, and execute projects with effective organizational, prioritization and problem‑solving skills
• Stay abreast of scientific and regulatory landscape; actively present (premier conferences), publish (peer‑reviewed journals) and patent
• Serve as Subject Matter Expert for intensified and/or continuous bioprocessing
• Mentor and actively share expertise; guide career development; build strong, collaborative teams

• Ph.D. with 3+ years, MS with 5+ years, or BS with 8+ years of industry experience and background in Chemical/Biochemical engineering, or a related field

• Strong fundamental knowledge and subject matter expertise in downstream process development
• Experience in continuous biomanufacturing and experimentation with integrated purification steps
• Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of downstream process development
• Track record of accomplishments in downstream bioprocessing with a history of peer‑reviewed publications and presentations
• Adaptability and agility to prioritize and deliver complex objectives, often on tight timelines, in a rapidly changing environment
• Experience and aptitude to lead, work, and collaborate in internal and external cross‑functional, matrixed teams
• Action‑oriented mindset for creativity; ability to take initiative, innovate, iterate, and problem‑solve
• Demonstrated commitment to coach and mentor staff to maximize talent development and utilization
• Excellent interpersonal and communication skills

• Excellent interpersonal and communication skills
• Experience with purification steps integrated with process‑analytical technologies
• High‑throughput experimentation, automation, and process control
• Experience with single‑pass ultrafiltration and in‑line diafiltration
• Experience with high throughput experimentation using automation platforms such as TECAN
• Experience using and/or programming process control systems such as Delta
  
  V or PCS 7
• Experience with multi‑column chromatography systems (BioSMB, PCC, or similar)
• Experience with statistical data analysis tools and design of experiments (JMP, Design Expert)
• Experience with multivariate data analysis, machine learning, artificial intelligence
• Experience with process modeling packages such as Bio Solve Process, gPROMS, Super Pro Designer, or similar

• Accountability
• Artificial Intelligence (AI)
• Automation
• Biomanufacturing
• Career Development
• Cell Line Development
• Column Chromatography
• Continuous Deployment
• Detail‑Oriented
• Downstream Process Development
• Drug Delivery Technology
• Drug Development
• Ex…