Associate Scientist, Cell Assays

We’re seeking a hands‑on scientist to execute high‑throughput cell‑based assays in 384‑well format. You will culture and plate cells, dispense compounds using the Echo, run diverse detection readouts, and analyze dose–response data to deliver high‑quality EC50 results for discovery programs.

• Maintain, expand, and plate mammalian cell lines for 384‑well assays
• Set up and execute assays with compound dispensing via Labcyte/Beckman Echo
• Run and optimize detection formats (e.g., luminescence, cAMP, HTRF/TR‑FRET, fluorescence)
• Generate dose–response curves (4‑parameter logistic fits) and report EC50/IC50 with QC
• Troubleshoot assay performance, optimize Z’ factors, and document SOPs/results
• Collaborate with discovery teams to prioritize studies and timelines

• BS/MS in Biology, Pharmacology, Biochemistry, or related field; 2+ years industry or equivalent lab experience
• Proficiency in mammalian cell culture and 384‑well assay workflows
• Hands‑on experience with Echo acoustic dispensing
• Experience with plate readers and assay platforms (e.g., cAMP, HTRF, luminescent assays)
• Strong data analysis skills: 4PL curve fitting, EC50/IC50 determination, and curve QC (e.g., R², top/bottom constraints)
• Detail‑oriented, organized, and comfortable in a fast‑paced, high‑throughput environment

• Experience with automation/LIQ handlers, LIMS/ELN, and statistical QC (Z’, CV, S/B)
• Familiarity with Graph Pad Prism, Activity Base, or equivalent analysis tools
• Hands‑on experience with Echo acoustic dispensing