Principal Scientist, Early Development Chemistry, Molecule Process R&D

Position: Principal Scientist, Early Development Chemistry, Small Molecule Process R&D

Principal Scientist, Early Development Chemistry, Small Molecule Process R&D

Merck invites applications for the Principal Scientist, Early Development Chemistry, Small Molecule Process R&D position. This role will lead and oversee the scientific work of external partner teams, providing daily oversight and real‑time problem solving across synthetic route design, scouting, optimization, development, and API delivery for our small‑molecule pipeline.

Nature and Scope of Position

• Reports to the Early Development Chemistry Lead within the External Capabilities group of Small Molecule Process R&D.
• Provides daily scientific oversight and real‑time problem solving in synthetic route design, scouting, optimization, development, and API deliveries.
• Collaborates effectively with Process Chemistry, Discovery Process Chemistry, Enabling Technologies, Chemical Engineering R&D, Analytical R&D, Quality, and other internal partner groups to ensure successful API deliveries under tight timelines.

Qualifications

• Education Requirement: Ph.D. in Synthetic Chemistry.
• Required Experience: 6+ years of pharmaceutical industry experience in synthetic chemistry and proven ability to lead and inspire dynamic teams.
• Strong track record of delivering results via innovation and fearless problem solving.
• Experience driving the supply strategy and science of new modalities.
• Excellent interpersonal, communication, negotiation, influencing, and collaboration skills.
• Recognized in the pharmaceutical industry through publications and presentations in synthetic chemistry.
• Travel:
  Yes, 25% of the time.

EEO Statement

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights, EEOC GINA Supplement, and other relevant resources.

Salary Range

$ — $ (based on education, qualifications, certifications, experience, geographic location, government requirements, and business needs). Eligible for annual bonus and long‑term incentives.

Benefits

We offer a comprehensive package of benefits, including medical, dental, vision, and other insurance benefits (for employee and family), retirement benefits (including 401(k)), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at

Application Process

You can apply for this role through  (or via the Workday Jobs Hub if you are a current employee). The Final date to receive applications for this position is stated on the posting. The job posting end date is 12/16/2025.

Seniority level

Associate

Employment type

Full‑time

Job function

Research, Analyst, and Information Technology

Industries

Pharmaceutical Manufacturing, Biotechnology Research, Research Services

Geographic Eligibility

US and Puerto Rico Residents only.

Employee Status

Regular

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