Senior Scientist - Discovery Analytical Research; On-site

## Senior Scientist
- Discovery Analytical Research (On-site)
Apply:
Not Applicable:
USA
- New Jersey
- Rahway:
Full time:
Posted Today:
End Date:
October 16, 2026 (7 days left to apply):
R421394
** Job Description
** We are seeking a highly motivated and innovative
** Senior Scientist
** to join our Discovery Analytical Research (DAR) group within the Analytical Enabling Capabilities (Analytical R&D) organization in Rahway, NJ. In this pivotal role, you will apply state-of-the-art analytical platforms, separation sciences, high-resolution mass spectrometry, automation and digital tools to accelerate drug discovery pipelines and directly influence the design and selection of next-generation therapeutic candidates.  Working at the dynamic interface between discovery and early development, you will lead analytical method development across chemical modalities including small molecules, macrocyclic peptides, complex linker-payloads, and synthetic intermediates.

You will collaborate closely with cross-functional teams to solve complex scientific challenges, champion novel analytical technologies, and drive data-backed candidate selection at discovery interface.  
** Primary Responsibilities*
* * Design, optimize, and execute robust chromatographic separation methodologies, including HPLC, UHPLC, Supercritical Fluid Chromatography (SFC), and Size Exclusion Chromatography (SEC) integrated with multi-detector systems (UV-Vis, CAD, and MS) to characterize the critical physicochemical properties of small molecules and peptides.
* Serve as a technical subject matter expert in High-Resolution Mass Spectrometry (HRMS) and tandem mass spectrometry (MS/MS) for structural confirmation and
* de novo
* sequence/structure elucidation of complex macrocyclic peptides and synthetic small molecules.
* Contribute to evaluation and implementation of next-generation measurement technologies and high-throughput workflows and automated liquid handling systems (
* e.g.*, Tecan, Bravo, Lynx).
* Contribute to continuous improvement in laboratory efficiency by implementing automated data-processing and digital workflows that accelerate analytical sample processing, database curation, and data visualization.
* Partner proactively with discovery teams, championing technical initiatives that elevate departmental capabilities, presenting scientific findings/updates at project meetings.
* Uphold the highest standards of data integrity, electronic laboratory notebook (ELN) documentation, and Good Documentation Practices (GDP) in accordance with organizational policies.
** Education & Experience Requirements**
* ** Ph.D.
** in Analytical Chemistry, Biochemistry, or a related scientific discipline;
** OR**
* ** Master’s Degree (M.S.)
** in Analytical Chemistry or a related scientific discipline with
** 7+ years
** of relevant biopharmaceutical industry experience.
** Required Experience and Skills*
* * Deep expertise in HPLC/UHPLC method development and LC-MS characterization applied to synthetic small molecules and cyclic peptides.
* Experience in MS-based structural confirmation, and de novo elucidation of small molecules and complex peptides.
* Hands-on experience operating, tuning, and troubleshooting modern Q-TOF, Orbitrap mass spectrometers (e.g., Thermo, Sciex, Waters, or Agilent).
* Demonstrated capability to balance multiple project priorities independently within tight timelines while maintaining scientific rigor.
* Proven capability to drive technical initiatives, and collaborate effectively across multifunctional project teams.
* Excellent written and verbal communication skills, underscored by a strong record of first-author publications in peer-reviewed journals and presentations at major scientific conferences.
** Preferred Experience…