Senior​/Executive Director, Reverse Translation, Oncology Translational Research

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Discovery & Pre-Clinical/Clinical Development

Translational Discovery & Development Biomarkers

Scientific/Technology

Cambridge, Massachusetts, United States of America, Raritan, New Jersey, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for an Senior/Executive Director, Reverse Translation (Oncology Translational Research) position in Spring House, PA, Cambridge, MA or San Diego, CA. This is a cross-functional leadership role with scope across the entire oncology therapeutic area. The leader runs a laboratory-based reverse-translation group within Translational Research - a talented and highly interactive translational group - built in alignment with Discovery, and consolidates bench scientists currently spread across disease-area programs into a single team.

This leader is a member of the Core SLT for Translational Research.

The role carries two mandates. First, it independently leads and is resourced to pursue key mechanistic questions across the TA, developing those insights into hypotheses that inform ongoing programs and the pipeline. Second, it responds to active scientific-support questions from the disease-area TR leads - working their mechanism, resistance, and combination questions in the laboratory. The common thread is working backward from clinical observations to biology, in close collaboration with Discovery and with Clinical, Medical Affairs, and Commercial partners.

• Lead independent studies on high-priority mechanistic questions that cut across the TA, with the mandate and resources to pursue them.
• Prioritize across three question types: disease-focused/cross-MOA, MOA-focused/cross-disease, and shelved programs mined for learnings that inform live assets.
• Develop findings into next-generation hypotheses and combination strategies that feed pipeline growth with Discovery.
• Take in and prioritize active mechanistic questions from the disease-area TR leads across all solid and heme indications.
• Lead laboratory-based research to address why programs work, why they fail, and how resistance develops - returning usable answers on a defined clock.
• Design and test combination strategies that potentiate benefit and break resistance.
• Build and run the lab; consolidate DAS-program scientists under one leader, and structure resources to support deep expertise on the different key anticancer MOAs.
• Own the platform - omics, functional/perturbation biology, and in vitro/in vivo and organoid models - for mechanistic characterization of drugs and TR samples.
• There may be opportunity to grow the team strategically as the mandate expands.
• Serve as a member of the Core SLT for Translational Research, contributing to org-wide scientific strategy and priorities.
• Serve as the…