Senior Medical Director, Oncology Clinical Development

Senior Medical Director, Oncology Clinical Development
- Sarcoma

Locations: UK – London – New Oxford Street | USA
- Massachusetts
- Waltham | UK
- Hertfordshire
- Stevenage | Switzerland
- Zug | USA
- Pennsylvania
- Upper Providence

For candidates seeking to be located at our Stevenage site, this role will temporarily be based ever, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK’s Switzerland (Zug), UK (Stevenage or London HQ) or US (PA or MA) sites.

• Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation
• Provide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standards
• Interpret complex clinical and safety data, generating insights that inform programme‑level decisions led by the CDL
• Partner with the Senior Scientist and cross‑functional teams to ensure medical considerations are integrated across study execution and programme delivery
• Provide senior medical input into protocol development and study design, ensuring clinical relevance and patient‑centred design within the clinical strategy defined by the CDL
• Serve as a senior member of the CMT, influencing study‑level and programme‑level decision‑making
• Engage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums
• Provide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capability

• consistency in approach, patient safety, and protocol adherence
• Guide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit–risk evaluation across the programme
• Participate in and contribute to safety review forums (e.g., SRT, IDMC), providing senior physician perspective on complex safety questions
• Ensure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standards

• Provide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDL
• Guide clinical aspects of study design and protocol implementation, particularly for complex, high‑risk, or multi‑study programmes
• Support resolution of complex medical questions arising during study conduct, applying clinical judgement to inform programme‑level decision‑making
• Ensure consistency of medical considerations across multiple studies within the programme

• Interpret complex clinical data across studies, integrating findings to inform programme‑level insights on safety, efficacy, and patient impact
• Contribute to programme‑level data interpretation and support CDL‑led benefit–risk assessment and clinical positioning
• Guide development of scientific communications, including publications, congress materials, and clinical summaries
• Maintain deep understanding of disease biology, evolving treatment paradigms, and competitive landscape to inform clinical interpretation and programme strategy

• Contribute senior medical expertise to…