Scientist​/Senior Scientist, Protein Design

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Syst Immune is a leading and well‑funded clinical‑stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi‑specific, multi‑specific antibodies, and antibody‑drug conjugates (ADCs). Syst Immune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing trials, Syst Immune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND‑enabling stages, representing cutting‑edge biologics development.

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

Syst Immune Inc. is looking for a creative and motivated Protein Design Scientist or Senior Scientist to work in our Computational Protein Design group. As part of the early scientific team, this individual will be involved in executing and improving the Computational Protein Design pipeline, using data‑driven approaches to augment Syst Immune Inc’s first‑in‑class multi‑specific biological programs.

The ideal candidate will have industry experience applying computational methods to design novel peptides and proteins, such as structural modeling and prediction, structure library generation, molecular docking, and multi‑parameter molecular property optimization. A successful candidate will be an excellent collaborator working closely with our Antibody Discovery, Protein Engineering, and Immuno‑oncology teams.

• Execute and improve a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody‑based elements via data‑driven approaches.
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display‑based protein discovery platforms.
• Design new macromolecular therapeutics using structural and sequence analysis, and employ these in‑silico predictions to iteratively guide the lead development process.
• Analyze, interpret, document and present data to the scientific and leadership team.
• Work within a collaborative, interdisciplinary team to actively contribute to executing the vision of the company.

• PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
• 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required.
• Experience solving problems related to peptide and protein design, modeling, and sequence/structure‑function prediction, and experience with relevant macromolecular modeling software (e.g., Alpha Fold, RoseTTAFold, RF diffusion, Protein
  
  MPNN, Gromacs, MOE, Schrödinger).
• Expertise in screening and ranking of antibodies (ELISA, multi‑parameter flow cytometry, BLI/OCTET).
• Proven contribution to therapeutic antibody development and selection is desirable. Design and validate novel and biologically relevant antibodies is highly desirable.

The expected base salary range for this position is $150,000 - $250,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills. While most offers typically fall within the low to mid‑point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

Syst Immune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and more.

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.