Principal Process Engineer – ECO Synthesis
Listed on 2026-10-05
-
Engineering
Process Engineer
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Description
Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a
Department
55 - ECO Process Development
Employment Type
Full Time
Location
Redwood City, CA
Workplace type
Onsite
Description
Codexis, a biotechnology company based in Redwood City, CA, is looking to hire a Principal Process Engineer – Flow Biocatalysis for Oligonucleotide Synthesis. Codexis is a leading enzyme engineering company leveraging its proprietary Code Evolver technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis.
The Company is currently developing its proprietary ECO Synthesis platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis enzymes can drive improvements, such as higher yields, reduced energy usage and waste generation, improve efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications.
To meet the goals we’ve set for ourselves, we look for individuals who are driven, eager to grow and ready to embrace meaningful challenges. We empower employees to be authentic, ambitious, agile and have the courage to take action where they can make a positive impact.
Come join us on this journey to transform the enzyme engineering landscape for the betterment of human health.
About the Opportunity: We are seeking a highly experienced and innovative Principal Process Engineer to lead the development, scale-up, and optimization of flow biocatalytic and oligonucleotide synthesis using the ECO Synthesis platform s role is critical in advancing our platform technologies and ensuring robust, scalable, and cost-effective manufacturing processes for therapeutic siRNA assets. If any of the below describes you, we would love to meet you!
- Possess a passion for being part of the therapeutic community helping bring cutting edge treatments to patients in need.
- Enjoys collaboration across different functional groups to get a holistic understanding of process development along with aligning data with internal stakeholders.
- Enjoys problem solving by implementing engineering and analytical solutions.
- Oversee process modeling, kinetic analysis, and reactor design (e.g., packed-bed, CSTRs, fluidized bed) for biocatalytic and/or oligonucleotide processes for RNA assets.
- Translate bench-scale and enzymatic processes into commercial-scale manufacturing workflows, ensuring regulatory compliance and cGMP readiness at scale.
- Conduct risk assessments and implement process control strategies using QbD (Quality by Design) principles.
- Drive external collaborations including CDMOs, equipment vendors, and academic institutions for innovative solutions and technology scouting.
- Collaborate with cross-functional teams including R&D, Analytical Development, MSAT, and Manufacturing to integrate ECO Synthesis platform into production pipelines.
- Author technical reports, protocols, and regulatory documents including CMC sections to support IND and NDA filings.
- Ph.D. in Chemical Engineering, Biochemical…
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