Senior Director, Clinical Business Planning

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity Revolution Medicines is focused on developing targeted therapies for patients with RAS-addicted cancers. The Senior Director, Clinical Business Operations and Strategy will lead the financial and business planning capabilities that support delivery of the global clinical development portfolio.

As a member of Clinical Operations, this leader will oversee study and departmental budgets, forecasting, workforce and resource planning, vendor financial management, and investigator site budgets and payments. Working closely with Clinical Operations leadership and Finance, the Senior Director will translate clinical development priorities into funded, achievable operating plans and provide clear recommendations on spending, capacity, and financial risk.

The role will lead and develop the Clinical Business Operations and Strategy team and partner with study teams, Global Vendor Outsourcing, Finance, Legal, and other development functions to maintain reliable financial information and support timely study delivery.  The lead will oversee a team that does the following:

Key Responsibilities:

Clinical budgeting and forecasting

Lead annual budgeting, periodic reforecasting, and long-range financial planning for Clinical Operations, consolidating study, program, and departmental requirements to support the Corporate Finance planning cycle.

Oversee study budget builds from protocol planning through closeout. Maintain documented assumptions for countries, sites, enrollment, patient visits, treatment duration, vendor scope, and internal resources.

Maintain estimates to complete and total projected study costs; assess the financial impact of protocol amendments, enrollment changes, timeline shifts, and portfolio decisions.

Lead regular budget reviews with study teams.

Provide finance with latest understanding of study plans and the financial impacts.

Explain actual and forecast variances, and recommend corrective actions or funding reallocations.

Facilitate clinical inputs to monthly and quarterly accruals, expense forecasts, and reconciling work performed for Finance.

Clinical Operations resource planning

Own the Clinical Operations capacity planning process, mapping employee, contractor, and outsourced resource needs to study milestones, workload, and portfolio priorities.

Partner with functional leaders, Finance, and Human Resources on headcount plans, hiring timing, contractor utilization, and staffing costs. Recommend resource allocation within approved budgets and escalate capacity gaps.

Evaluate alternative staffing and delivery models, identifying opportunities to improve utilization and manage costs while protecting study quality and timelines.

Vendor budgets and invoice oversight

Oversee the financial performance of contract research organizations and other clinical vendors, including approved budgets, purchase order funding, invoiced amounts, accruals, and remaining obligations.

Partner with Global Vendor Outsourcing and study teams to evaluate vendor proposals, cost assumptions, payment schedules, and change orders; assess affordability and forecast impact before commitments are approved.

Establish invoice review and reconciliation processes that verify charges against contractual rates, authorized scope, milestones, and services confirmed by study teams. Resolve discrepancies with vendors and Accounts Payable.

Monitor vendor spending and change order trends, identify potential overruns early, and lead financial escalations and recovery of credits or unused advances through final reconciliation.

Site budgets and payment forecasting

Oversee investigator site budget financial review, including country and site assumptions, per-patient costs,…