Senior Data Scientist RWE), Life Sciences R&D

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

The Real World Evidence (RWE) group within the Life Sciences R&D team at Tempus works with major pharmaceutical partners to provide best-in-class data, analysis, and methodological guidance for Tempus’s real-world data offering.

• Pharma Collaboration & Strategy:
  Lead the design and execute delivery of RWE analyses for key pharma clients. You will be responsible for translating complex drug development questions and into actionable research plans that use Tempus data for trial design and outcomes research.
• Real World Data Expertise:
  Lead the derivation of complex real-world endpoints using extensive coding, demonstrating deep comprehension of Tempus clinical and molecular data structures and complexity, while also serving as an expert on the methodological nuances and limitations of real-world data.
• Methodology & Platform Contribution:
  Build technical standards for the team, staying up-to-date on methodological advancements in real-world studies (e.g., causal inference, survival analysis) and oncology guidelines (NCCN and ongoing clinical trials). Contribute to reusable code and internal packages that can be applied across multiple collaborations.
• AI & LLM Innovation:
  Incorporate LLMs, agentic workflows and other AI tools into day-to-day workflows to accelerate code development, discovery, documentation, review, and insight generation.
• Scientific Interpretation & Communication:
  Interpret results of RWE analyses to draw appropriate inferences based on study design/statistical methods, while also evaluating study limitations. Communicate complex methods and results clearly to both technical and non-technical stakeholders. Prepare and present internal reports, external-facing deliverables, and, where appropriate, manuscripts or conference materials.
• Cross-Functional Collaboration:
  
  Collaborate with internal product, oncology, and clinical abstraction, and real-world data science teams to continually enhance Tempus data quality, products, and analytical best practice. You will proactively identify gaps in current products and ensure that customer feedback is represented in development of new products.
• Oncology & RWE Domain Expertise:
  Grow and maintain deep expertise in oncology clinical guidelines (e.g., NCCN) and emerging RWE methodologies.

• Education:
  
  Education in epidemiology, biostatistics, data science, public health, or a related field, to the level of either:
• PhD and 2+ years of additional work experience
• Master’s degree and 4+ years of additional work experience
• Technical and Statistical Proficiency
• Expert-level proficiency with observational real-world healthcare data, including analytical experience with time-to-event methodologies (survival analysis).
• Proven expertise in executing RWD analytical studies.
• Proficient in using R and SQL, especially statistical tools and packages.
• Proficiency applying machine learning, LLM-based coding assistants (e.g., Claude Code, Copilot, Cursor) and agentic frameworks to support data analysis, code review, or scientific documentation workflows.
• Adherence to good software engineering practices (version control, modular code, documentation).
• Experience with code review.
• Communication & Client Focus:
  Demonstrated experience interfacing with clients, showcasing adeptness in presenting and tailoring messaging to a variety of stakeholders.
• Soft Skills:
  
  Excellent written…