Microglia Scientist

Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to rejuvenate cell and tissue function with the ultimate aim of adding 10 years to healthy human lifespan.

We are seeking an experienced new member of our Microglia Therapeutics team who will bring well‑rounded experience working in Alzheimer’s disease research to help us bring our cell therapy to the clinic!

You approach your work with a growth‑mindset, eager to use your critical thinking skills and problem‑solving abilities. You enjoy hands‑on work and value being honest, organized, and paying attention to details. You’re a highly collaborative team member with a “can‑do” attitude and great communication skills.

• Design and execute experiments to support our research goals.
• Perform regular culture and differentiation of iPSCs to multiple CNS cell types using aseptic tissue culture techniques.
• Troubleshoot and optimize 2D and 3D (organoids) differentiation protocols.
• Develop cell‑based and molecular assays to characterize the cells and prove function.
• Collaborate seamlessly within the Microglia Team and across Retro teams such as In‑Vivo, Computational Biology, Automation, Process Development, etc.
• Help the team solve technical challenges and suggest mitigation strategies.
• Actively participate in brainstorming sessions to develop adaptive strategies for overcoming obstacles.
• Analyze, interpret and present experimental data to our internal teams and collaborators.
• Maintain an organized electronic lab notebook and contribute to supporting documents.
• Participate in regular lab organization activities and ordering.

• Have a Ph.D. in Neuroscience, Biology or related field and at least 3 years of relevant post‑degree experience in academia or industry.
• 3+ years of experience working on Alzheimer’s Disease research.
• Are familiar with neurodegenerative diseases and ways to accurately model different aspects of neuropathology.
• Experience with iPSC tissue culture, cell‑based assays and in vivo models of neurobiology.

• Have experience with differentiation of iPSCs to brain cell‑types.

$130,000 - $170,000 a year

At Retro, we don’t use titles. New hires join as a “Member of X Team.” Depending on experience, this role could flex from what might be traditionally regarded as Associate Scientist to a Scientist level.

Total compensation also includes generous equity and benefits including:

• Medical, dental, and vision insurance for you and your family
• 401(k) plan with 4% matching
• Flexible time off and 10 company holidays per year
• Paid parental leave
• Annual learning & development stipend
• Monthly Longevity stipend
• Daily Retro-sponsored lunch and snacks

We take pride in cultivating an environment that fosters collaboration, open communication, and authenticity. We believe that great results are best delivered by a highly creative team working in concert. We are an equal opportunity employer; we do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We are diverse in background and singular in mission.