Scientist II, Process Chemistry

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

We are seeking a gifted experimentalist to join our team as a laboratory-based process chemist to own development work streams for a small-molecule drug substance. You will independently design and execute experiments, solve complex chemistry problems, and develop robust processes suitable for scale-up and technology transfer. This is a hands-on individual contributor role with responsibility for scientific recommendations and delivery of assigned development objectives.

Own the development of reactions, process steps, or development work streams, setting experimental approaches and coordinating work to meet agreed project objectives.

Design and execute experiments to evaluate alternative routes and optimize reactions, workup, isolation, and crystallization conditions.

Investigate complex reaction behavior and impurity formation using mechanistic reasoning, experimental design, comparison of analytical data, and understanding relevant scientific literature.

Develop robust processes by defining parameter sensitivity, reproducibility, impurity control, solubility limits, and other practical requirements for manufacturing.

Plan and execute laboratory studies and translate results into recommendations for process implementation at large-scale.

Prepare technology transfer procedures and work with external contract development and manufacturing organizations (CDMOs) to resolve implementation issues.

Author process development reports and technical content supporting regulatory documentation; maintain complete electronic laboratory records.

Provide scientific guidance to research associates, present recommendations to project teams, and identify and address laboratory and process safety risks.

Required Skills, Experience and

Education:

PhD in organic chemistry and at least 2 years of related experience, which may include postdoctoral research.

Demonstrated ability to independently design and execute process development studies and solve complex synthetic chemistry problems.

Strong hands-on skills in multistep synthesis, reaction optimization, isolation, and characterization using NMR, chromatography, and mass spectrometry.

Ability to connect experimental results with process robustness, scale-up considerations, and project objectives.

Experience taking responsibility for a defined scientific workstream and providing technical guidance to colleagues.

Clear scientific writing, effective collaboration, and proficiency with electronic laboratory notebooks, data analysis tools, and Chem Draw.

Preferred

Skills:

Industry experience in pharmaceutical process development, laboratory scale-up, crystallization, or technology transfer to CDMOs.

Experience with design of experiments, automated laboratory reactors, cGMP manufacturing, or drug substance regulatory documentation.#LI-CT1 #LI-Hybrid The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is…