Senior/Principal Scientist, Material and Analytical Sciences
Listed on 2025-12-03
-
Engineering
Research Scientist, Chemical Engineer, Biotechnology
Senior / Principal Scientist, Material and Analytical Sciences
Boehringer Ingelheim is currently seeking a Senior or Principal Scientist to support our Material and Analytical Sciences team at our Ridgefield, CT facility. This role is part of Boehringer Ingelheim’s Drug Substance–Drug Product Interface organization, driving innovation in small molecule development. The principal scientist/senior scientist will lead efforts in solid‑state chemistry and API engineering, focusing on phase‑appropriate isolation processes and DS‑DP co‑processing technologies to ensure optimal material attributes—purity, crystal form, and physical properties.
This position offers the opportunity to shape strategies for next‑generation drug substance/drug product integration, collaborate across CMC Development and Operations, and implement cutting‑edge solutions in manufacturing.
As an employee, you will contribute to the discovery, development, and delivery of our products to patients and customers. Our global presence provides opportunities to collaborate internationally, offering visibility and direct contribution to the company’s success. We support our employees with a healthy working environment, meaningful work, mobility, networking and work‑life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim’s high regard for employees.
Duties & Responsibilities- Lead experimental design and hands‑on execution for solid form, crystallization and isolation, and DS‑DP co‑processing development, applying QbD principles and appropriate engineering tools.
- Champion DS‑DP Co‑processing as a platform technology; drive implementation across the portfolio.
- Develop scalable crystallization and isolation processes, identifying CPPs and establishing robust control strategies.
- Conduct solid form screening (polymorphs, salts, co‑crystals) and advanced characterization using XRD, DSC, TGA, DVS, Raman, and PAT tools.
- Collaborate with cross‑functional CMC teams to ensure process robustness, scalability, and tech transfer to GMP manufacturing.
- Resolve scale‑up challenges related to crystallization, particle engineering, and DS‑DP integration; perform risk assessments and mitigation planning.
- Author technical reports, regulatory documentation, and contribute to IND/NDA filings.
- Serve as a scientific leader and mentor, fostering innovation and knowledge sharing within Material & Analytical Sciences.
- Stay ahead of emerging technologies (AI/ML, automation, continuous crystallization) and regulatory trends.
- Strong expertise in solid‑state chemistry, polymorphism, crystallization development, and Drug Substance‑Drug Product interface.
- Proven ability to design processes, generate and analyze data, and interpret results independently.
- Hands‑on development of cGMP isolation processes and scale‑up principles.
- Excellent communication and collaboration skills; ability to influence in a matrix environment.
- Physical requirements:
lift/carry up to 50 lbs.; respirator use may be required. - Appropriate level of understanding of applicable regulations.
- Ph.D. in Chemical Engineering, Organic Chemistry, Pharmaceutical Science, Polymer Science, or related field or equivalent experience.
- Broad knowledge of field.
- Appropriate level of understanding of applicable regulations.
- Ph.D. in Chemical Engineering, Organic Chemistry, Pharmaceutical Science, Polymer Science, or related fields, or equivalent with at least 5 years related experience.
- At least 4 years post‑graduation of pharmaceutical industry or relevant industrial experience in chemical engineering, process chemistry, physical chemistry or related fields.
- 1–3 years of project management/leadership experience.
- Proven track record of publication in peer‑reviewed journals.
- Experience in polymer science and DS‑DP co‑processing.
- Familiarity with predictive modeling tools, PAT, and CFD.
- Application of AI/ML for process optimization and digital development strategies.
This position offers a base salary typically between $140,000 and $222,000 USD, with potential variable or performance‑based bonus and other compensation elements. For an overview of benefits, please visit the company website.
Eligibility Requirements- Must be legally authorized to work in the United States without restriction.
- Must be willing to take a drug test and post‑offer physical (if required).
- Must be 18 years of age or older.
We provide opportunities to develop your own path in a company that values diversity, fosters innovation, and supports employees with access to health and wellbeing programs. Learn more at
#J-18808-Ljbffr(If this job is in fact in your jurisdiction, then you may be using a Proxy or VPN to access this site, and to progress further, you should change your connectivity to another mobile device or PC).