Senior Scientist, Translational Biomarkers

Overview

Senior Scientist, Translational Biomarkers – Arcellx

Join to apply for the Senior Scientist, Translational Biomarkers role at Arcellx.

Arcellx is a public, clinical-stage biotechnology company reimagining cell therapy by engineering innovative immunotherapies for patients with cancer and other incurable diseases. We believe that cell therapies are one of the forward pillars of medicine and our mission is to destroy cancer and advance humanity by developing cell therapies that are safer, more effective, and more broadly accessible. Our team members work from our offices in Rockville, Maryland, and Redwood City, California in a collaborative, inclusive environment.

• Living our core values is essential to maintaining a high-performing, inclusive, and collaborative work environment. We look for candidates who demonstrate strong values alignment and bring different backgrounds, viewpoints, and abilities to the team.
• The Arcellx Core Values:
  Start with authenticity;
  Think “we” before “me”;
  Embrace the challenge.

• Design, develop, validate and execute robust fit-for-purpose clinical biomarker assays to support secondary and exploratory endpoints in clinical safety and efficacy studies.
• Ensure biomarker methods are compliant with ICH Q2 guidelines and meet regulatory standards.
• Manage the transfer, bridging and validation of biomarker assays at CROs.
• Contribute to biomarker plans and strategies for addressing key translational questions.
• Analyze, interpret, prepare and present data summaries, communicate next steps and provide recommendations to internal teams and stakeholders.
• Contribute to regulatory document preparation.
• Identify, evaluate and integrate new technologies to support evolving translational biomarker strategies.
• Write and review SOPs, technical protocols and reports.
• May supervise associate scientists and support their professional development.

• PhD in immunology, immuno-oncology, molecular and cellular biology or related field.
• 5+ years of biomarker experience in the pharmaceutical industry.
• Strong understanding of various technology platforms and datasets used to support clinical biomarker assays in early to late phase trials.
• Strong technical expertise in developing, validating and implementing clinical biomarker, immunological, molecular and gene expression assays.
• Subject Matter Expert (SME) on validation of analytical methods per ICH Q2 guidelines.
• Strong data analysis capabilities for high dimensional data using Flow Jo or data packages such as Cytobank; knowledge of R and/or Python is preferred.
• Experience managing CROs and ensuring high-quality, timely delivery of biomarker data with an understanding of ICH/GCP and regulatory requirements.
• Strong problem-solving skills and ability to independently oversee scientific projects, analyze data with attention to detail.
• Effective communication skills with the ability to present complex data to diverse audiences.
• Experience working in a GCLP-regulated environment and knowledge of GLP/GCP-compliant studies.

• Estimated base salary range: $125,000 - $145,000 per year. A bonus based on company goals and an equity (RSU) grant are part of the compensation package. Relocation assistance is available if required.
• Benefits include 100% coverage for medical, dental and vision for team members and dependents, unlimited vacation, a 3-day weekend every month, fully-paid parental leave for up to 6 months, tuition reimbursement, 401k employer contribution and more.

Join us in our quest to reimagine cell therapy and destroy cancer. For more on our technology, culture, and team, go to .