Senior Director, Translational Biomarkers

Senior Director, Translational Biomarkers

Job Category:
Research

Requisition Number: SENIO
001881

Posted:
September 14, 2025

Full-Time

Hybrid

Locations

Headquarters, 9704 Medical Center Dr, Rockville, MD 20850, USA

Macro Genics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. Macro Genics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

We are seeking a highly innovative and motivated scientist to join the Research Department as a Senior Director, Translational Biomarkers. This individual will evolve and lead the Translational Biomarkers function that is responsible for defining and implementing biomarker strategies to inform translational oncology objectives for our ADC and immuno-oncology pipeline. Key areas of focus will include defining optimal target populations/patient segments, predictive efficacy and safety biomarkers, PK/PD relationships, mechanisms of drug resistance, and supportive evidence for combination strategies.

This role will require cross-functional collaboration with pre-clinical and clinical functions and data management, as well as with all Translational Medicine functions including translational bioinformatics, pathology, flow cytometry, and toxicology.

Responsibilities

• Develop and lead a Translational Biomarkers function within the Translational Medicine organization whose principal remit is to define and implement cutting-edge translational approaches that directly inform both clinical and preclinical development

• Work cross-functionally within Translational Medicine, as well as with preclinical and clinical teams, to define data-driven, rational translational strategies with a clear link to development impact

• Evolve knowledge of, and capabilities relating to, advanced translational technologies such as spatial
-omics and multimodal data analysis designed to elucidate novel insights that inform translational objectives

• Contribute to strategies, planning, and implementation for CDx development where indicated

• Contribute to development of streamlined operational workflows to ensure efficient translational data handling, including but not limited to data import, QC processes, method development and standardization, and criteria for internal/external presentation

• Participate in development of SOPs for translational data analysis that incorporate the use of both internal and external data sources

• Participate in business development activities, including establishing and maintaining good collaborative alliance/academic relations

• Participate in and serve in a leadership role for company-wide scientific initiatives

• Promote external visibility through presentations at scientific meetings and through scientific publications

Education and Experience

• MD or PhD in molecular biology or related field

• Minimum of 12 years of related experience in industry/academia with focus on oncology drug development

• A minimum of four (4) years of experience supervising scientific employees

Knowledge,

Skills and Abilities

• Deep knowledge base in tumor biology and applications to oncology drug development with demonstrable track record in successfully developing, applying and implementing translational biomarker strategies with development impact

• Substantial experience designing and implementing data analysis plans in collaboration with data scientists and bioinformaticians

• Broad and thorough understanding of drug development and clinical trial methodology

• Ability to develop innovative analytic approaches to complex…