Antibody Engineering Lead

Our client in the biotechnology sector is growing their Antibody Engineering team and is in search of a skilled scientist with extensive knowledge in guided phage display and the development of antibody discovery technologies.

Primary Responsibilities:

Enhance and progress phage display techniques — including guided selection methods, structure-informed panning, and epitope-focused strategies — expanding platform capabilities beyond traditional campaign execution.

Utilize deep mutational scanning and NGS-based analysis to gain mechanistic understanding, guide library design, and construct predictive models of antibody fitness landscapes.

Create innovative phage display selection methods for complex targets like membrane proteins and conformational epitopes.

Contribute to intellectual property and propel the field forward through inventorship and impactful publications.

Collaborate with structural biology to utilize cryo-EM, crystallography, and molecular dynamics data for informed engineering decisions.

Incorporate AI/ML and computational tools into phage display workflows, using generative protein design, protein language models, and in silico affinity prediction to speed up lead identification and optimization.

Qualifications:

PhD in Molecular Biology or a related field.

Experience in advanced phage display with a focus on method and technology advancement.

Preference for a strong publication record demonstrating impact.

Interest in bridging experimental and computational antibody engineering.