Scientist, Computational Protein Engineering

This position is responsible for developing a protein-engineering platform in collaboration with other scientists in the group and across the company. The incumbent will be responsible for designing and executing experiments and analyzing data to further product development and research goals. This position may/will supervise the work of others directly and/or across interdisciplinary teams.

• Develop a protein engineering platform in collaboration with other scientists in the group and across the company
• Define computational pipelines for protein structure determination using structural and/or sequence-based methods and/or artificial intelligence techniques (e.g. Rosetta, Alpha Fold)
• Generate computational workflows for protein-target interactions, including but limited to enzyme-DNA/RNA interactions
• Design and execute laboratory experiments to evaluate protein-engineering efforts.
• Provide input to the management team to identify, develop, and execute departmental initiatives and strategies.
• Present findings/analyses and any associated issues/solutions to peer groups and managers; make recommendations for project advancement.
• Specific duties may vary depending upon departmental requirements.

• Ph.D. in structural biology, biophysics, biochemistry, bioengineering, computational biology, or related field with up to four years of industry or academic experience
• Experience with protein modeling, including protein-target interactions
• Publications in the form of high-profile papers/patents within protein prediction or de novo protein design, including enzyme engineering.
• Experience with artificial intelligence and/or machine-learning methods is desirable.
• Supervisory experience preferred

• Proven record of remaining current, learning new techniques/research in the areas of structural biology/protein engineering.
• Ability to work independently and in teams, to collaborate with external parties, in a highly dynamic and collaborative environment
• Leadership skills with demonstrated knowledge and understanding of staff management practices and processes and the ability to establish accountabilities and expectations and manage performance to achieve results
• Problem solving skills and demonstrated ability to organize and move project tasks forward in an orderly and structured fashion.
• Strong analytical skills with the demonstrated ability to gather and evaluate complex data and information and develop a recommendation and plan of action.
• Excellent organizational, planning, and time management skills required, with the ability to manage multiple and often changing priorities and issues of varying complexity while meeting time-sensitive deadlines and deliverables.
• Demonstrated propensity to be creative, collaborative, proactive, and self-motivated in the execution and completion of assigned tasks.
• Strong communication (written and verbal) skills regardless of the format (e.g., documents, public speaking situations, presentations, etc.).
• Proven proficiency with Microsoft Office (i.e., Word, Excel, PowerPoint, and Outlook).

• While performing the duties of this job, the individual is frequently required to sit and stand for long periods. The individual is occasionally required to walk; use hands and fingers to operate, handle, or feel objects, tools, or controls; reach with hands and arms.
• Up to 50 % of the day may be spent at a laboratory bench.
• There are aspects of the position’s duties that require a person in this role to work at heights above four (4) feet on occasion and move/lift up to 25 pounds.

• Laboratory environment working with chemical reagents and performing some Biosafety Level 2 work
• May involve handling of BSL-2 materials and organisms including human blood and/or blood products

The annual base salary for this position ranges from $98,800. to $150,700. This salary range represents a general guideline as MSD considers other factors when presenting an offer of employment, such as scope and responsibilities of the position, external market factors, and the candidate’s knowledge, skills, abilities, education and experience. Employees may qualify for a discretionary or non-discretionary bonus in addition to their base salary.

These annual bonuses are intended to recognize individual performance and enable employees to benefit from the Company's overall success.

At MSD, we offer a comprehensive…