Lead Research Scientist - Pharmacology

Our client is seeking a dynamic Lead Research Scientist with extensive experience in Pharmacology to spearhead critical drug development programs at their facility in Rustenburg . This senior role will involve designing and overseeing preclinical studies, characterizing drug candidates, and contributing to regulatory submissions. You will lead a talented team of pharmacologists and technicians, ensuring the rigorous scientific execution of projects from target validation through to early clinical development.

The ideal candidate will possess a deep understanding of drug action, disease mechanisms, and regulatory requirements, playing a key role in advancing novel therapeutics to meet unmet medical needs.

• Design and manage comprehensive preclinical pharmacology studies to evaluate drug efficacy and safety.
• Develop and validate bioassays and pharmacodynamic models relevant to disease areas of interest.
• Analyze and interpret complex experimental data, providing key insights into drug mechanisms of action.
• Lead and mentor a team of scientists and research associates, fostering a high-performance research environment.
• Collaborate closely with discovery chemistry, DMPK, and toxicology departments to advance drug candidates.
• Prepare study reports, contribute to regulatory filings (e.g., INDs), and present findings to internal stakeholders and external partners.

• Ph.D. in Pharmacology, Toxicology, or a related life science discipline.
• Minimum of 6 years of experience in drug discovery and development, with a focus on pharmacology.
• Proven expertise in various in vivo and in vitro pharmacology models .
• Strong understanding of drug metabolism, pharmacokinetics (DMPK), and toxicology principles.
• Demonstrated leadership experience, with the ability to manage and motivate a research team.
• Excellent written and verbal communication skills, with a strong publication record.

• Competitive salary and comprehensive bonus package.
• Extensive health, dental, and vision insurance plans.
• Generous paid time off and holiday schedule.
• Opportunities for professional development and attending scientific conferences.
• A collaborative and innovative research environment dedicated to improving patient outcomes.