Postdoctoral Researcher

Position Summary

Our group studies both genomic and non-genomic actions of thyroid hormones. Current projects map membrane-initiated receptor/signaling networks—spanning cytokines, growth factors, and GPCR pathways—that drive genomic, structural, and functional adaptations in the heart and vasculature. We place special emphasis on β-adrenergic desensitization, septic cardiomyopathy, and vasoplegia, with the long‑term goal of informing the development of new therapeutics to improve survival in sepsis.

We will leverage the following capabilities:

• Molecular biology: cloning, vector design, EMSA, protein–protein/DNA–protein interaction assays.
• Cell & tissue platforms: primary cells, iPSC‑derived cardiomyocytes, tissue models.
• Imaging & physiology: live‑cell biosensors, super‑resolution microscopy, patch‑clamp electrophysiology.
• Omics: targeted proteomics and transcriptomics.
• In vivo models: small and large‑animal models of septic shock and myocardial dysfunction.

• Design and execute experiments; analyze and interpret data with rigor and reproducibility.
• Drive manuscripts, figures, and conference abstracts/presentations.
• Collaborate across cardiology, critical care, and biostatistics teams; mentor junior trainees as appropriate.
• Contribute to protocol/IRB/IACUC documents and lab SOPs.

• PhD (or equivalent) in Molecular & Cell Biology, Biochemistry, Biomedical Sciences, or a related field.
• Hands‑on expertise in core molecular and cell biology (cloning/construct design, PCR/qPCR, EMSA or related DNA‑binding assays, immunoblot/Co‑IP, primary cell culture).
• Strong quantitative skills, clear scientific writing, and a record of productivity (publications or preprints).

• Experience with GPCR/β‑adrenergic or thyroid hormone signaling.
• Proficiency in protein–protein interaction assays, reporter systems, or chromatin methods.
• Advanced live‑cell imaging.
• Familiarity with animal models of cardiovascular disease or sepsis; AALAS/IACUC training.

UC Davis offers an outstanding, interdisciplinary environment with access to state‑of‑the‑art cores (genomics, imaging, proteomics) and close ties to critical care and cardiology programs. The position provides strong mentorship toward career independence and grant writing.

• Start date:
  
  Flexible (review of applications begins immediately and continues until filled).
• Term: 1‑year initial appointment, renewable based on performance and funding.
• Compensation:
  Commensurate with experience and aligned with UC/NIH guidelines; full UC benefits.

Email a single PDF to Joaquin Lado, MD, PhD  with:

• Cover letter describing your research interests and fit.
• CV.
• Names/contact information for three references.

Application requirements include disclosure of any misconduct investigations and submission of an Authorization to Release Information as per UC Davis policy.