Research Mechanistic Cancer Research - Molecular Oncology

Overview

As a curiosity-driven cancer biology lab, we are broadly interested in uncovering novel cancer targets with the overarching goal of improving patient outcome. Currently, we are focusing on dissecting the complex molecular mechanisms governing genome stability which plays an important role in cancer initiation, progression, and treatment response. Our studies center around two multi-functional proteins, the actin-binding protein Profilin-1 and the AAA+ ATPase p97/VCP.

Both are essential proteins with well-known functions in the cytoplasm, but play important yet poorly understood roles in the nucleus. Our recently published work and ongoing studies link nuclear Profilin-1 and p97/VCP to transcription, DNA replication, and DNA damage repair and signaling. We believe that mechanistic insights from such studies can reveal hidden Achilles heels of cancer cells, and guide the development of novel and personalized treatments.

Standard and specialized molecular, cellular, and animal procedures are performed in the lab, including cell culture, fluorescence microscopy, Western blot, immunoprecipitation, PCR, cloning, genetic mouse models, mouse xenografts, DNA fiber, and proximity ligation assays.

• For more information about the lab and our research, visit: http://(Use the "Apply for this Job" box below)..org
• Visit: .html
• Visit: /

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

• Required Qualifications
  Bachelor’s degree or combination of education and/or experience may substitute for minimum education.
• Certifications
  No specific certification is required for this position.
• Work Experience
  No specific work experience is required for this position.
• Skills
  Not Applicable
• Driver's License
  A drivers license is not required for this position.

• No additional education beyond what is stated in the Required Qualifications section.
• No additional certification beyond what is stated in the Required Qualifications section.
• No additional work experience beyond what is stated in the Required Qualifications section.
• Skills:
  
  Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. See the benefits page at  for details.

Washington University is committed to equal employment opportunity and encourages applications from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. The University is dedicated to building an inclusive environment with respect for all backgrounds, experiences, and perspectives.