Senior Scientist - Genetics

Overview

The Senior Scientist in the Cremins Lab will work with a dynamic team to conduct research in the area of the generation and analysis of new multimodal imaging data for mapping the neural connectome at synapse resolution using RNA barcodes.

Position Details
Scheduled

Hours:

40

• Collaborates on designing, conducting and reporting of research projects and assists with grant preparation.
• Supervises and conducts Illumina linkering, library preparation for all genomics experiments, quantification, library pooling, and placing sequencing runs for the lab.
• Generates novel in situ sequencing imaging datasets to understand structure-function relationships of neuronal connectomes using confocal microscopy and microfluidics.
• Processes and analyzes imaging and sequencing data (image registration, segmentation, feature detection, clustering, anchoring to single cell datasets).
• Oversees and writes established SOPs for new and existing molecular sequencing technologies, computational algorithms.
• Prepares and reviews papers on research.
• Develops new algorithms for analysis of RNA FISH, DNA FISH, and neural connectome in situ sequencing technologies.
• Collaborates fluidly with other computational experts to conduct efficient analyses leading to discovery in mammalian neuron genome structure-function data.
• Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Performs other duties as assigned.

• Works in a laboratory environment with potential exposure to biological, chemical and radioactive hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

• Education:
  
  PhD Or Terminal Degree Or Combination Of Education And Experience May Substitute For Minimum Education.
• Certifications:
  
  No specific certification is required for this position.
• Work Experience:
  
  Postdoctoral (3 Years)
• Skills:
  
  Not Applicable

• PhD in cell biology, imaging, computational biology or neuroscience.
• 3+ years of postdoctoral experience is highly preferred.
• Experience in imaging and technology development is highly preferred.
• Experience in multi-modal genomics omics, spatial transcriptomics, computational biology, in vivo AAV or lentivirus injections, behavioral neuroscience, or electrophysiology is a plus.
• Experience with Illumina library preparation and handling Next Seq
  1000/2000 and Nova Seq instruments is a plus from the perspective of mentoring someone else for genomics sequencing.
• Experience in Python/R programming language, Linux environment, and cluster computing is strongly preferred.
• Experience in statistical analysis of imaging data is strongly preferred.
• Ability to work independently and apply critical thinking and sound judgment.

Salary Range: $63,400.00 - $ / Annually

The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

Questions:
For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation:
If you are unable to use our online application system and would like an accommodation, please email Candidate Questions or call the dedicated accommodation inquiry number and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening:
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

EEO Statement:
Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

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