Director, IT

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single‑molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight.

To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world‑class team of builders, innovators, and dreamers across a wide range of disciplines.

As the Director of IT
, you will drive the technological vision of our company, ensuring our systems are scalable, secure, and innovative. This role requires a forward‑thinking leader who thrives in a fast‑paced environment.

This position reports to the Senior Director of Software Engineering and IT and can be located in Seattle, WA or San Carlos, CA.

• Develop and implement IT strategies that align with organizational goals.
• Lead IT operations across infrastructure, hardware, networking, systems management, ensuring reliability, scalability, and performance.
• Ensure data security, compliance, incident response and disaster recovery protocols are in place.
• Oversee IT budgets, vendor relationships, and procurement processes to ensure cost‑effective and value‑driven technology investments.
• Provide regular updates to senior leadership on IT budget performance, risk posture, cybersecurity initiatives, and strategic priorities.
• Identify and implement emerging technologies to improve business processes.
• Implement AI strategy for increased organizational efficiency, decision‑making, and operational outcomes.
• Collaborate with software, operations, and legal teams to define and enforce enterprise‑wide data governance policies and practices.
• Partner with engineering, operations, finance, and software teams to enable technology‑driven commercialization efforts.
• Drive the selection, integration and management of business systems (ERP, HRIS, PLM, CRM, etc.) crucial to operations and commercialization efforts.
• Play an integral role in product definition, requirements specification and execution.
• Champion Dev Ops practices driving infrastructure‑as‑code (IaC), automation, continuous integration and continuous delivery (CI/CD) pipelines.
• Inspire, mentor, and grow high‑performing IT teams, fostering a culture of innovation, accountability, and cross‑functional collaboration.
• Set and communicate clear team priorities, ensuring alignment with company strategy and responsiveness to evolving business needs.
• Build and reinforce scalable, actionable processes that empower teams to make informed decisions and deliver consistent results.
• Foster collaboration between development and operations teams to streamline deployment processes and improve system reliability.
• Navigate and lead teams through change, leveraging competitive insights and innovative thinking to adapt and thrive in dynamic environments.

• Bachelor’s degree in information technology, information systems, computer science or a related field.
• 12+ years of IT experience, with 8+ years in a managerial role.
• Expertise in cloud computing (preferably AWS and Azure), network design and infrastructure, and enterprise software.
• Experience managing Dev Ops, driving IaC, automation, CI/CD pipelines, and collaboration between development and operations teams.
• Experience deploying security and SaaS tools across organizations.
• Deep understanding of IT architecture and cybersecurity.
• Strong familiarity with software development practices.
• Strong leadership and project management skills.
• Experience with regulatory standards across data privacy, security, financial data management (GDPR, CCPA, HIPAA, SOX, ISO
  27001, etc.).
• Requires bimonthly travel between office locations.
• We are curious go‑getters: this is a team of life‑long learners who aren’t afraid to tackle the big challenges, and we embrace the journey.
• We are detail‑oriented: we do great science by working smart & with diligence where we learn from our trials and mistakes.
• We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness.

$189K - $252K