Associate Scientist​/Scientist , Analytical and Formulation Development

Associate Scientist/ Scientist I, Analytical and Formulation Development

About The Company Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies.

The Company's lead development candidate, DR-01, induces antibody‑mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody‑based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease‑causing agents.

Function Analytical and Formulation Development

Level Associate Scientist / Scientist I

Location San Carlos, CA

Reporting Manager Director, Analytical and Formulation Development

About The Opportunity Dren Bio is seeking a highly motivated individual to support antibody characterization and formulation development for the Company’s pipeline programs. The successful candidate will work as a bench Scientist to conduct analytical and bioanalytical method and formulation development and be involved in interactions with contract development and manufacturing organizations (CDMOs). This position offers excellent potential for contribution and visibility at an early‑stage company and opportunities for career development.

• Develop ELISA and cell‑based analytical methods for activity and potency testing to support batch release, stability, and formulation development.
• Develop HPLC, capillary electrophoresis based analytical methods for antibody characterization to support batch release, stability, and formulation development.
• Apply scientific principles, current technologies, and personal experience to design and execute appropriate experiments to solve challenges in analytical method development.
• Work closely with colleagues in other functional areas to ensure timely analytical support for cell line, process, and formulation development.
• Partner with discovery teams to perform manufacturability assessments to support selection of clinical candidates.
• Contribute to CMC sections in IND submissions and BLA submissions.
• Facilitate the development of SOPs for various analytical methods and the qualification of methods required for technical transfer to CMO/CRO facilities.
• Maintain and troubleshoot analytical instrumentation as required and troubleshoot assay performance as needed.
• Guide junior staff in development work.
• Document experimental work in notebooks, SOPs, and reports.
• Communicate results and provide updates at internal and external project team meetings.

• BS or MS degree in Biochemistry, Analytical Chemistry or related field.
• 6+ years (for BS) or 4+ years (for MS) of experience in the biopharmaceutical industry for Associate Scientist.
• 8+ years (for BS) or 6+ years (for MS) of experience in the biopharmaceutical industry for Scientist I.

• Hands‑on knowledge of technical scientific principles for ELISA and cell‑based assays. Proficient in assay development and able to troubleshoot anomalous data.
• Hands‑on knowledge of technical scientific principles for HPLC/UPLC (reverse phase, ion exchange, size exclusion), capillary electrophoresis.
• Familiarity with techniques to measure protein characteristics such as Tm and stability assessments to support formulation development.
• Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts.
• Experience with performing develop ability or manufacturability assessments for therapeutic…