Principal Scientist, Mass Spectrometry

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

• Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
• Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision.
• Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

• Contribute creatively to the scientific direction of the Institute by ideating, challenging, and advancing bold, high-impact research opportunities.
• Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery.
• Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation.
• Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities.
• Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation.
• Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights.
• Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs.
• Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields.

• May be a contact for external CRO partners when needed
• May provide matrix or line-function leadership for project teams when needed

• Proficiency with mass spectrometry data acquisition, processing, and analysis software.
• Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets.
• Experience with software and tools for MS-based screening and assay development.

• Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred.
• Deep expertise in mass spectrometry, with demonstrated hands-on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation.
• Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows.
• Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights
• Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation.
• Experience developing and optimizing sample preparation,…