Principal Scientist, Early Discovery & Immune Cell Engineering

Principal Scientist, Early Discovery & Immune Cell Engineering# Careers at BeOne## Principal Scientist, Early Discovery & Immune Cell Engineering Apply:
San Carlos:
Full time:
Posted Today:
R37361

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.
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* General Description:

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* ** Candidates must be able to work onsite in San Carlos, California.
** At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles:

* Bold exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles.
* Strategic alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision.
* Pipeline impact: we translate insights into tangible assets and advance emerging platforms into impactful programs.

We are seeking a strategic and highly adaptive
** Principal Scientist
** to lead early discovery programs within our agile biotech ecosystem. This role requires a unique blend of laboratory execution, matrix leadership, and a rigorous
** drug-development mindset.
** As a Principal Scientist, you will play a critical role in shaping BeOne’s early discovery pipeline. Operating in a highly dynamic environment, you will help evaluate and determine our optimal therapeutic bets—whether that means developing a novel cell therapy platform, or identifying other high-potential modalities across Immuno-Oncology (IO) and Immunology & Inflammation (I&I). This position demands an individual who balances deep literature research with hands-on bench execution, possesses a collaborative spirit, and confidently brings independent, innovative hypotheses to the table.

** Essential Functions of the Job:*
* * Drive early discovery strategy, evaluate emerging scientific opportunities and literature to guide internal pipeline decisions.
* Advance immune cell engineering platforms to deliver novel cell therapies for oncology and immunology indications.
* Build, optimize, and deploy high-throughput screening platforms using pooled and arrayed approaches.
* Develop robust, quantitative cell-based immunology assays to characterize therapeutic potency.
* Lead hands-on execution of in vitro and ex vivo studies to generate decision-enabling data packages.
* Lead cross-functional matrix teams, collaborate with experts across the organization and mentor junior scientists to foster technical excellence, scientific rigor, and professional growth.
* Distill and present complex biological data packages
* Contribute to operational and management activities to support objectives at the San Carlos site.
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* Supervisory Responsibilities:

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* * May directly manage scientists and/or provide matrix leadership for project teams.
** Requirements:*
* ** Travel:
** No  
* Ph.D, M.D., or equivalent advanced degree in Immunology, Molecular Biology, Bioengineering, or a related scientific discipline with 5+years of dedicated biotech or pharmacutical industry experience.
* Extensive, hands-on expertise in molecular biology (cloning, construct design, IVT mRNA synthesis) alongside deep proficiency in modifying primary immune cells using both viral (e.g., lentivirus) and non-viral (e.g., electroporation, CRISPR/Cas9, transposons) methodologies.
* A clear track record of navigating drug discovery programs. You prioritize actionable, milestone-moving data over open-ended academic…