RayzeBio Scientist, Radiochemistry

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Rayze Bio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. Rayze Bio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, Rayze Bio aims to be the global leader in radiopharmaceuticals.

This position will be responsible for conducting research, experiments, and analysis in the field of radiochemistry. This role involves radiolabeling of diagnostic and therapeutic radioisotopes of peptides, small molecules, and/or antibodies as well as quality testing for in vitro and in vivo work. The Scientist will work in laboratory settings, collaborating with interdisciplinary teams to advance scientific knowledge and contribute to the advancement of all Rayze Bio’s internal programs.

• Essential duties and responsibilities include the following. Other duties may be assigned.
• Develop methods and conduct experiments to radiolabel peptides, small molecules and/or antibodies using various isotopes.
• Develop and execute methods for the characterization of radio labeled compounds, using techniques such as radio-HPLC and radio-TLC chromatography to analyze purity and stability of the radio labeled compounds.
• Develop methods and recipes and perform regular syntheses of radiotracers on automated synthesis devices.
• Develop methods and conduct in vitro assays (e.g., plasma stability and metabolite analysis) with radio labeled compounds.
• Collaborate with interdisciplinary teams of discovery scientists and researchers as well as external partners (such as CROs) to address complex scientific questions and pursue collaborative research projects.
• Analyze experimental data, interpret results, and draw conclusions based on scientific principles. Document findings in technical reports and presentations for internal review and meetings.
• Present at meetings to provide timely input to progress the programs forward.
• Maintain a clean and safe working environment.

• A Ph.D or Master’s degree in radiochemistry, chemistry, nuclear chemistry or related field.
• A minimum of 3 years of experience in radiochemistry field.
• Demonstrated experience in radiochemistry synthesis, purification, and quality control instruments such as HPLC, TLC and gamma counter.
• Proper radiation safety practices during radio synthesis, radio analytical chemistry operations, and within the lab areas at all times.
• Ability to work both collaboratively and independently in a fast-paced and cross-functional environment with evolving priorities.

• Hands on experience working with diagnostic radioisotopes (F-18, Ga-68, Cu-64, Zr-89) and therapeutic radioisotopes (Lu-177, Ac-225, Tb-161, Pb-212).
• Experience working with automated synthesis modules.
• Highly motivated and organized professional with the ability to work both with a team and independently.
• Multi-disciplined scientist with ability to troubleshoot.
• Excellent professional ethics, integrity, and ability to maintain confidential information.

While performing the duties of this position, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The…