Director, Program Management

Janux Therapeutics is seeking a Director, Program Management to lead the planning and execution of one or more of Janux’s clinical and early development programs. This role serves as a senior integrator across cross‑functional teams and plays a pivotal role in shaping program strategy, driving execution, and aligning organizational priorities. The successful candidate will bring extensive oncology drug development expertise, strategic leadership, and exceptional communication and facilitation skills.

This position reports to the Vice President, Program & Portfolio Management, with matrixed accountability to Project Team Leaders, functional leads and executive stakeholders. This is a unique opportunity to contribute to the transformation of a pioneering immuno‑oncology biotech and to lead high‑impact programs from concept through clinical development and commercialization.

• Provide strategic leadership for cross‑functional drug development teams, ensuring strict alignment with corporate goals and scientific priorities.
• Partner with Project Team Leader (PTL) to drive the development and execution of integrated program strategies, including timelines, budgets, risk mitigation plans, and resource allocation.
• Oversee planning and execution of key drug development milestones (e.g., IND, IP availability, FIP, data readouts, regulatory filings), ensuring cross‑functional coordination and accountability.
• Drive decision‑making and issue resolution at the program level, proactively identifying risks and implementing mitigation strategies.
• Apply deep understanding of oncology drug development practices to assist PTL in identifying and planning for key strategic inflection points and stage gates to de‑risk next phase of development and other ongoing programs within the portfolio.
• Serve as a key liaison between program teams and executive leadership, delivering critical updates, strategic recommendations, and facilitating governance interactions.
• Anticipate, identify, and resolve program risks, issues, resource gaps and acceleration opportunities.
• Present critical program updates, strategic recommendations, and respond to questions from senior leadership and governance bodies.
• Lead continuous improvement initiatives to enhance portfolio planning data integrity, streamline workflows, and optimize vendor and team collaboration.
• Establish, maintain and enforce best practices in program management, knowledge sharing, and operational excellence.
• Facilitate transparent communication across department subject matter experts and with external partners to ensure program alignment and momentum.
• Mentor and guide junior program managers and contribute to the growth of the Program & Portfolio Management function.
• Represent Janux externally with partners, vendors, and regulatory bodies as needed.
• Perform other duties as assigned.

• Bachelor’s degree in Life Sciences, Biotechnology, Project Management, or a related field. Advanced degree preferred.
• Minimum of 10 years of program management experience in the biotech or pharmaceutical industry.
• Proven track record in managing programs from early development and through late‑stage clinical milestones, including regulatory submissions, within oncology programs.
• Deep understanding of biotech industry standards, regulatory frameworks, and clinical development processes.
• Strong leadership presence with the ability to influence across all levels of the organization.
• Excellent strategic thinking, communication, and interpersonal skills.
• Proficiency in project management tools and software (MS Project preferred).

$207,000 - $225,000 a year

In addition to a competitive base salary ranging from $207,000 to $225,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as…