Principal Scientist, Protein Sciences

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iBio, Inc. is a preclinical stage biotechnology company leveraging the power of Artificial Intelligence (“AI”) for the development of hard-to-drug precision antibodies in the cardiometabolic and obesity space. Our core mission is to harness the potential of AI and machine learning (“ML”) to unveil novel biologics which other scientists have been unable to develop. Through our innovative AI Drug Discovery Platform, we have been able to identify differentiated molecules aimed to address unmet needs by current glucagon-like peptide-1 (“GLP-1”) receptor agonists.

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Are you a visionary scientist ready to lead antibody innovation from discovery to clinic
? iBio is looking for a Principal Scientist, Protein Sciences to head our protein sciences group and drive cutting-edge therapeutic antibody development, with a focus on bispecific formats
.

This role is located in San Diego, CA.

In this role, you will:

• Drive the design, engineering, and optimization of therapeutic antibodies, with a strong emphasis on bispecific formats and develop ability considerations.
• Perform comprehensive antibody characterization using methods such as ELISA, SPR, HPLC, BLI, and related assays.
• Oversee mammalian expression systems and provide leadership in protein purification and manufacturability testing.
• Lead, mentor, train, and manage members of the Protein Sciences group, including Scientists and Research Associates.
• Collaborate closely with cross-functional teams to ensure seamless progression of programs from platform discovery through in vivo proof-of-concept studies and into development.
• Communicate research findings effectively to internal stakeholders, senior leadership, external partners, and the broader scientific community as needed.
• Contribute to regulatory documentation, support development, and ensure adherence to industry standards and best practices.
• Drive innovation and intellectual property generation, including publications and patents where appropriate.
• Stay current with scientific literature and emerging technologies to continuously strengthen the company’s protein sciences capabilities.

• Extensive hands-on experience with antibody discovery, engineering, and development, including demonstrated leadership of antibody programs in a biotech or pharmaceutical setting.
• Proven expertise with multiple bispecific antibody formats, with a strong track record of assessing and guiding develop ability.
• Deep technical experience in mammalian protein expression, purification, and analytical characterization using standard assays (e.g., ELISA, SPR, HPLC, BLI).
• Experience with antibody fusions, Fc-fusions, and conjugation to antibodies is highly desirable.
• Demonstrated ability to integrate deep knowledge in at least one disease area to shape and advance therapeutic programs.
• Industry experiences advancing biologic therapeutics from discovery through development, with contributions to clinical candidates.
• Successful track record of leading and mentoring scientific teams, as well as managing external collaborations with CROs or academic partners.
• Evidence of innovation and scientific leadership, including patents, publications, or conference presentations.

• Bachelor’s degree in Biochemistry, Biophysics, Molecular Biology, or related field and 10+ years of experience within the biotech/pharmaceutical industry; or,
• Master’s degree in Biochemistry, Biophysics, Molecular Biology, or related field and 8+ years of experience within the biotech/pharmaceutical industry; or,
• PhD degree in Biochemistry, Biophysics, Molecular Biology, or related field and 5+ years of experience within the biotech/pharmaceutical industry.

• Critical Thinking and Scientific Expertise: Strong critical thinking skills with proven expertise in antibody development, safety, and pharmacokinetics.
• Cross-Functional Collaboration: Demonstrated success in working effectively with cross-functional project teams in fast-paced environments.
• Communication
  
  Skills:
  
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