Principal Scientist - In-vitro Display

Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

The Biotechnology Discovery Research group at Lilly’s Biotechnology Center in San Diego discovers medicines that address significant unmet needs by integrating biology with innovative scientific capabilities in protein engineering and computational sciences. We collaborate with colleagues in both the discovery and development organizations, including scientists in therapeutic area biology, biomolecule formulation and develop ability, ADME, Toxicology, PK/PD, Statistics, Computational Biology and clinical development.

We are seeking a highly motivated and organized scientist to contribute to the discovery and development of biotherapeutics. This individual will be responsible for working in a dynamic team environment and be a contributor to multiple work streams, including in vitro display systems for novel antibody discovery, flow cytometry applications, and recombinant antibody expression and characterization. This position requires hands-on experience with flow cytometry, experience in tissue culture, and an understanding of biochemistry and molecular biology especially pertaining to techniques for protein engineering.

The successful candidate is expected to set up and execute experiments, be detail oriented, skilled at data analysis and troubleshooting and will be accountable for preparing and presenting data at lab meetings with guidance regarding required tasks and expected results.

• Discover, engineer, and optimize antibodies using in vitro display technologies to improve biological function, develop ability, and immunogenicity profiles

• Use biochemical and functional assays to evaluate antibody-antigen interaction including ELISA, cell binding and signaling assays, Octet or other SPR-based techniques

• Demonstrate strong expertise in molecular and cellular biology techniques including western blotting, PCR, cell culture, and site-directed mutagenesis.

• Experience with antibody fusions, Fc-fusions, and conjugation to antibodies is highly desirable.

• B.S./M.S. in a relevant field with at least 6+ years industry experience in molecular biology, biochemistry, or protein engineering

• Proven hands-on experience with fundamental biology techniques, including: cell culture, viability assays, transfections, Western blot, affinity assays, image-based assays

• Strong experience in molecular biology including standard cloning techniques, sequence analysis, DNA and RNA extraction, ligation, PCR.

• Experience with flow cytometry is highly desirable

• An understanding of antibody discovery, particularly with respect to in vitro display systems

• Excellent communication skills with a desire to be involved in collaborative, cross

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