Postdoctoral Associate -Postdoctoral Associate, Cell Biology & Immunology

ABOUT US

Cali
-Skaggs, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Cali
-Skaggs was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked the most influential institution in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading-edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Cali
-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re‑investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve well‑being. Cali ‑Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age‑related and degenerative diseases.

If you have a passion for making a difference, this could be your opportunity to join our transformative team.

Postdoctoral Associate, Cell Biology & Chemical Biology

The candidate will join an early-stage discovery research group at Cali ‑Skaggs. Under guidance and in collaboration with others the candidate will perform research in the areas of cell biology and chemical biology. Specifically, the candidate will work on hit‑to‑lead drug discovery of small molecule and peptide drug candidates discovered through Cali ‑Skaggs’ DNA‑encoded library (DEL) platform. The primary goal of the research is to discover novel therapies for immunology and inflammation.

The drug discovery pipeline at Cali ‑Skaggs spans early discovery to IND, and the candidate will be engaged throughout this process. A successful candidate will be self‑led and able to work both independently and collaboratively to lead research projects, analyze data and interpret results. The right candidate will be adaptable with a willingness to collaborate with others on a wide range of projects, and enthusiastically learn new skills/techniques.

• Work within discovery project teams and with scientists across different functional areas and be expected to present his or her work at project team meetings and to research leadership
• Work independently to design, execute, analyze, interpret and troubleshoot scientific experiments in cell and chemical biology
• Accurately maintain written reports and present results in an organized and timely manner to research leadership
• Communicate effectively with peers and supervisors, foster teamwork and contribute to collaborative efforts
• Strong commitment to quality in research and presentation
• Develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates
• Design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets
• Responsibilities include utilizing disease models to design target validation studies and relevant assays in support of SAR chemistry, mechanism of action, biomarker selection, and disease positioning

Candidates should have strong core competencies in research and an understanding of chemical and cell biology and associated biological techniques and assay development. Direct experience in immunology and inflammation is a plus, but not required. Candidates can expect to apply their basic understanding of research to learning drug discovery and development.

Experience and prior skill sets should include:

• Core knowledge of mammalian cell biology and chemical biology
• Specific knowledge in Immunology and Inflammation
• Experience with western blots, ELISA and/or AlphaLISAs
• Experience with PBMCs and other immunologically relevant cell types
• Experience…