Scientist, Oncology

The successful candidate will have extensive hands‑on experience in mammalian cell culture techniques, cell biology, and molecular biology assays. This position will be responsible for supporting efforts towards the development of combination therapies and studying its mechanism of action in various cellular models. This position will report to the Senior Scientist and will be a critical player in the group.

• Design, execute, and analyze/interpret experiments to advance mechanism of action studies, develop patient responder hypotheses, elucidate mechanisms of resistance and identify rational drug combinations that can be translated to the clinic.
• Develop assays to support biomarker selection and identification strategies to be incorporated into developmental programs.
• Utilize broad technical expertise in cell biology, tumor cell biology, immune cell biology, and in vivo animal models to design in vitro, in vivo, and ex vivo experiments to expand understanding of our therapeutics.
• Document experimental results and present them regularly at group meetings.
• Contribute to lab operations as required.

• Ph.D. in Biology with 0-2 years of experience in the field of oncology
• Experience in performing drug combination studies and characterizing cancer signaling pathways.
• Experience in genetic manipulation of cells via CRISPR and viral transduction, running cellular (2D and 3D viability, apoptotic, cell cycle), molecular and biochemical (q-PCR, western blot, ELISA, Jess) assays.
• Experience in target validation, functional and biomarker cell-based assay development.
• Proficient in cell biology including shRNA and CRISPR technologies.
• Experience in epigenetic profiling studies (DNA methylation, RNA-sequencing, ChIP-sequencing and ATAC-sequencing) and strong knowledge in enhancer-mediated regulation of the genome is a plus.
• Have deep understanding of cancer signaling pathways as evidenced by peer-reviewed publications.
• Ability to execute and troubleshoot experiments independently.
• Able to analyze, interpret and present data effectively.
• Able to adapt quickly to changing needs of the company and work collaboratively.
• Highly motivated, innovative and strong team player. Excellent time management and organizational skills.