Principal Research Scientist , Lipid Design and Formulations Development

ICompany

Description:

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

We are seeking a highly motivated and innovative Formulation Scientist to join our LNP development team. In this role, you will be responsible for leading projects focused on lipid design, formulation development, and characterization of targeted LNP drug products to support internal platform and pipeline programs. The ideal candidate will have a deep understanding of LNP formulation and lipid chemistry, analytical characterization and functional screening in vitro and in vivo.

• Independently lead research efforts through deep technical understanding and work collaboratively within a cross‑functional product development team to drive design, functional screening, development and production of novel tLNP formulations for targeted, extra hepatic delivery of nucleic acid payloads.
• Discover and optimize novel lipid designs and applications from diverse structural families for LNP platform technology development.
• Collaborate with various groups across the organization, including mRNA, analytical, conjugation, antibody and CMC process development groups to advance pipeline programs.
• Routinely act as a group leader on formulation projects and provide mentorship to a small group of research associates.
• Contribute to formulations/process development sections of regulatory filings (IND, NDA, etc.).
• Review scientific literature, patents, scientific abstracts to stay up to date on the latest in the field; provide scientific expertise with special emphasis on lipid nanoparticle‑based drug targeting delivery systems for nucleic acids.

• BS or equivalent education and extensive, typically 14+ years of industry experience; MS or equivalent education with typically 12+ years of industry experience;
  PhD with typically 6+ years of industry experience in the scientific area of discipline.
• Preferred:
  PhD in Chemistry, Biochemistry, Bioengineering or Pharmaceutical Sciences with experience in the design and development of nanoparticle‑based drug delivery systems or complex biologics.
• Deep technical prowess in lipid chemistry and LNP formulation; demonstrated ability to establish new capabilities and innovate strategies in pursuit of scientific excellence.
• Must possess an in‑depth understanding of all aspects of formulation development as well as downstream characterization, including physicochemical, stability and biological evaluation.
• Experience with process: lipid nanoparticle formulation and purification processes, and/or experience with process development, scale‑up/out, engineering and GMP manufacturing of biologic drug product processes is highly desired.
• Experience with supervision, mentorship, or training of other team members.
• Good track record of scientific publications and patents in lipid nanoparticle‑based drug delivery systems is desired.
• Must be an independent thinker with a passion for developing novel formulation technologies.
• Experience contributing to formulation and pharmaceutical development sections of regulatory filings is highly desirable.
• Details oriented with good organization skills, excellent troubleshooting, team player, and strong oral and written communication skills are necessary for this position.

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range.
  
  This range may be modified in the future.
• We offer a comprehensive package of benefits, including paid time off (vacation, holidays, sick), medical/dental/vision…