Scientist, Medicinal Chemistry

Scientist, Medicinal Chemistry

Neurocrine Biosciences is a leading neuroscience‑focused, biopharmaceutical company dedicated to discovering and developing life‑changing treatments for patients with under‑addressed neurological, neuroendocrine and neuropsychiatric disorders. Our diverse portfolio includes FDA‑approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis (in collaboration with Abb Vie) and uterine fibroids (in collaboration with Abb Vie), as well as a robust pipeline of compounds in mid‑to late‑phase clinical development across our core therapeutic areas.

Responsible for the design, synthesis, purification, and characterization of intermediates and bioactive compounds through the use of techniques such as column chromatography (e.g., high‑performance liquid chromatography, automated normal phase purification), nuclear magnetic resonance, and parallel or combinatorial synthesis. Prepares technical reports, summaries, protocols, and quantitative analyses, and communicates and presents results to the project team in order to facilitate effective decision‑making.

• Plays a key role in the rapid optimization of lead molecules utilizing modern technology available to medicinal chemists such as automated synthesis and purification.
• Participates in a multidisciplinary team committed to the continuous improvement of the lead optimization process as well as the expeditious identification of development compounds.
• Designs, plans, and conducts synthesis of intermediates and analog libraries and communicates results to the project or program team.
• Other duties as assigned.

• BS/BA degree AND 2+ years of relevant experience, including familiarity with parallel synthesis, lab automation, and purification in the optimization of lead compounds (preferred).
• MS/MA degree in Synthetic Organic Chemistry (preferred) AND some similar experience noted above.
• PhD in Synthetic Organic Chemistry or related field (preferred) AND some related postdoctoral experience (preferred).
• Working knowledge of organic synthesis, parallel synthesis, medicinal chemistry, lab automation, and purification in the optimization of lead compounds (preferred).
• Recognizes fundamental anomalies in data points and identifies issues in experiments/processes.
• Begins to understand how to think outside of the technical process and consider the impact decisions will have on broader scientific goals.
• Strong knowledge of scientific discipline, principles, methods and techniques; demonstrated ability working with a variety of laboratory equipment/tools.
• Strong computer skills; good problem‑solving, analytical thinking skills; detail oriented; ability to meet deadlines.
• Excellent communication skills with the ability to collaborate with cross‑functional scientists.

Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment and encourage you to apply even if your experience or qualifications don’t line up exactly with what we have outlined.

The annual base salary we reasonably expect to pay is $89,800.00–$. Individual pay decisions depend on factors such as work location, role complexity and responsibility, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity‑based long‑term incentive program. Benefits include a retirement savings plan with company match, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits covering medical, prescription drug, dental and vision.