Research Scientist- Phd- Molecule Medicinal Chemistry; Temporary

ABOUT US

Cali  is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. A division of Scripps Research and situated in the heart of San Diego's Torrey Pines Mesa biomedical research hub, Cali  is uniquely positioned to create and proliferate innovative partnerships. Cali 's research interests span a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases.

Cali  was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Leveraging the unique scientific framework of Scripps Research, Cali  has created a portfolio of drug candidates based on Scripps technologies and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research.

Cali  offers scientists from a wide range of disciplines the opportunity to apply their skillsets to creating transformative medicines - if you have a passion in making a difference, this is the opportunity for you.

Research Scientist-PHD

• Good hands‑on experience with crystallization, filtration and chromatography‑based processing methods along with small molecule analytical methods.
• Work closely with Cali 's scientists on development of lab‑scale synthetic, analytical and formulation projects.
• Works cross‑functionally to deliver high quality compounds in support of Cali 's preclinical drug discovery programs.
• Prepare technical reports, patent application content, publications and oral presentations as necessary.

• PhD in chemistry, medicinal chemistry, synthetic chemistry, bio‑organic chemistry or related field with experience in pharmaceutical/drug discovery industry.
• Proven track record of successfully overseeing structure‑activity development.
• In‑depth knowledge of synthetic organic chemistry and pharmacokinetics. Familiarity with common isolation methods including crystallization (batch and continuous mode), filtration and drying.
• Hands‑on experience including but not limited to the following analytical methods: RP‑HPLC, UV‑Vis; HR‑MS, LCMS‑QTOF, XRD and other analytical methods is required.
• Excellent interpersonal, verbal and written communication skills.
• Comfortable in a fast‑paced environment and able to adjust based on changing priorities.
• Highly motivated, creative, and devoted to project goals.

The expected hiring range for this position is $78,000-$103,000 per year, commensurate with experience. Consideration will be given to experience that exceeds the listed requirements.

This is a temporary position anticipated to end by April 30, 2026.

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions.

The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture, and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.