Senior Scientist Chemistry

Overview

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. This role involves opportunities to grow and thrive alongside high-achieving teams.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

The Sr. Scientist will design and synthesize novel chemical constructs as potential new RPT therapies for cancer treatments. The Sr. Scientist will be a highly motivated and technically skilled synthetic organic, peptide or medicinal chemist with excellent interpersonal and communication skills. The role will offer an opportunity to work as a functional lead on multiple projects ranging from target selection through candidate nomination stages and may lead early-stage projects in an interdisciplinary setting.

The role is highly technical and requires someone who enjoys leading from the bench with high productivity and data analysis skills in a fast-paced environment.

• Design and synthesize novel peptide/small molecule compounds in support of SAR campaigns for pipeline projects.
• Contribute toward developing SAR on assigned projects, design and synthesize key target molecules to assess chemical/biological hypotheses.
• Independently plan and execute organic synthesis routes for complex molecules. Utilize modern purification and analytical tools to support synthesis and characterization of target compounds.
• Work in close collaboration with interdisciplinary team members to provide needed chemistry support to guide programs through lead identification/optimization phases.
• Collaborate with chemists, DMPK, imaging and in vitro/vivo teams to ensure timely generation of target compounds to support the screening funnel.
• Contribute experimental efforts in support of target selection and initiation of new TRP projects.
• Keep abreast of the literature in the field of RPTs and identify novel concepts to advance the state of the art in the RPT field.
• Contribute toward IP filings and drafting of publications and presentations.
• Routinely present research findings and project updates in interdisciplinary team settings.
• Adhere to safety guidelines, regulatory standards, and company policies to ensure a safe working environment.
• Identify external partners, KOLs, and outside expertise to advance the pipeline.
• Supervise the work of junior scientists and ensure experimental rigor and high quality.

• PhD in synthetic organic, peptide or medicinal chemistry with 4+ years post-PhD/postdoc experience or BS with 15+ years experience in pharmaceutical/biotech R&D with demonstrated accomplishments.
• Experience in targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable.

• Well-versed in modern synthetic organic/peptide/med chem principles with a track record of high productivity.
• Strong scientific curiosity, problem-solving skills, and understanding of drug design, SAR analysis, ADME/PK.
• Ability to share data and collaborate with cross-functional teams; ability to interpret data and plan experiments without supervision.
• Excellent written and oral communication and presentation skills; ability to work in a fast-paced, dynamic, and collaborative environment.
• Experience supervising and guiding junior scientists in an industrial drug discovery setting.

Regularly sit and use hands, reach with arms, and talk or hear. May lift/move up to 30 pounds. Vision requirements include close and distance vision. Work in a laboratory environment with required protective clothing, gloves, and safety glasses. Some roles may involve handling radioactive materials.

Moderate noise level typical of a laboratory environment.

San Diego - Rayze Bio - CA: $131,028 - $158,775. Additional incentive cash and stock opportunities may be available. Final compensation will be based on experience. Benefits and eligibility vary by location. For more on benefits, visit the company career site.

• Health Coverage:
  Medical, dental, vision.
• Wellbeing and financial well-being programs, including 401(k) and life/disability insurance.
• Paid Time Off and holidays; additional time-off programs may apply.

BMS is committed to equal opportunity employment. Reasonable accommodations are available on request. See the EEO statement and accessibility information on the Careers site.

If you live in or work from Los Angeles County, additional information may be applicable per local regulations.

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