Research Associate, Research Scientist, Biotech Research

At HAYA Therapeutics, we are pioneering a new class of programmable RNA-guided therapeutics that target the regulatory genome to reprogram disease-driving cell states. By decoding the causal biology of pathological cell states and the long-noncoding RNAs (lncRNAs) that regulate them, HAYA translates these insights into tractable therapeutic candidates designed to address disease at its source and restore cellular health. HAYA is advancing a broad pipeline of RNA-guided medicines for chronic, age-related diseases.

Recognized globally for our scientific innovation, HAYA has been named a 2025 Technology Pioneer by the World Economic Forum (WEF), selected for Bio Space's Next Gen Bio Class of 2026, recognized as a 2026 Disruptive Pioneer by IDEA Pharma, and celebrated as one of the Top Innovative Companies in Switzerland for 2025. As a fast-growing biotech, we offer an entrepreneurial, science-driven environment where you’ll have a direct impact on shaping our pipeline and advancing RNA medicine

Execute preclinical cellular assays, tissue histology, nucleic acid extractions, and spatial transcriptomics protocols to generate high-quality experimental data supporting HAYA's functional genomics and lncRNA target validation pipelines.

• Execute primary cell isolation, tissue culture, and cell line maintenance (including human and mouse fibroblasts, C2C12 cells, myoblasts, and satellite cells) to establish robust in vitro disease models.
• Perform compound treatments and antisense oligonucleotide (ASO) screening protocols (including Gapme Rs and siRNA) across primary cell platforms to evaluate target knocking-down efficiency and therapeutic potency.
• Isolate and process RNA, DNA, and proteins from cellular and tissue specimens using standardized extraction techniques to prepare high-integrity samples for downstream molecular profiling.
• Tissue Histology & Spatial Transcriptomics
• Perform tissue processing, FFPE embedding, sectioning, and staining protocols (including immunohistochemistry and immunofluorescence) to quantify fibrotic markers and evaluate tissue morphology.
• Execute spatial transcriptomics and multi-omics assay workflows in alignment with functional genomics protocols to characterize spatial gene expression in target tissues.
• Capture and analyze fluorescence microscopy images across immunostained and spatial transcriptomic tissue sections to extract qualitative and quantitative cellular insights.
• Preclinical Model Support & Data Governance
• Support in vivo preclinical study workflows by assisting with tissue dissections and sample collection from skeletal mouse and disease models to supply downstream experimental work streams.
• Maintain detailed, real-time Electronic Lab Notebook (ELN) records, SOPs, and experimental documentation to ensure absolute data traceability, reproducibility, and audit readiness.
• Synthesize, analyze, and present experimental dataset summaries to internal R&D project teams and scientific leadership to inform ongoing pipeline decision-making.

• Cell Culture & Primary Model Proficiency:
  Demonstrated capability in primary cell isolation, propagation, and differentiation, with specific expertise in mammalian cell lines or primary fibroblasts/myoblasts.
• Molecular Biology & ASO Screening Techniques:
  Practical experience performing nucleic acid extractions (RNA/DNA), PCR, and compound/ASO transfection screenings.
• Histology & Imaging Capabilities:
  Hands-on experience with tissue sectioning (FFPE/cryosectioning), histology staining, immunofluorescence (IF), or fluorescence microscopy.
• Preclinical Sample Handling:
  Comfortable handling animal tissue samples from vivarium studies and maintaining strict chain-of-custody documentation.
• Technical Agility & Documentation Rigor:
  Proven ability to rapidly adopt new laboratory protocols, operate digital ELNs, and maintain meticulous attention to experimental detail.
• Educational Foundation:
  Bachelor’s or Master’s degree in Molecular Biology, Cellular Biology, Biotechnology, Biochemistry, or a related life sciences discipline.

• Next-Generation Sequencing (NGS) & Multi-Omics:
  Familiarity with NGS library preparation (RNA-seq, single-cell RNA-seq) or spatial transcriptomics platforms.
• Experience with automated liquid handling systems or other laboratory…